DCT
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Official Full Name
dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) -
Overview
Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene . Its expression is regulated by the microphthalmia-associated transcription factor (MITF). -
Synonyms
DCT;dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2);TYRP2;L-dopachrome tautomerase;L dopachrome tautomerase;Dopachrome delta isomerase;Dopachrome tautomerase;Dopachrome tautomerase dopachrome delta isomerase, tyrosine related protein 2;DT;EC 5.3.3.12;L dopachrome Delta isomerase;L-dopachrome Delta-isomerase;TRP 2;TRP-2;TRP2;Tyrosinase related protein 2;Tyrosinase-related protein 2;TYRP2_HUMAN;OTTHUMP00000018553;dopachrome delta-isomerase
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Myc
- SUMO
- T7
- GST
- Non
- Avi
- Fc
- DDK
- Flag
Involved Pathway
DCT involved in several pathways and played different roles in them. We selected most pathways DCT participated on our site, such as Melanin biosynthesis,Melanogenesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GMPPAA,TPH1,PRIM2,CYP3A7-CYP3AP1,GPAM,LCLAT1,GLB1,ENO2,IPMKB,NT5M |
| Metabolism of amino acids and derivatives | AMD2,SAT1B,SLC25A10,SLC6A7,AZIN1,NAGS,SLC6A12,CTHL,PAOX,AMDHD1 |
| Melanogenesis | GNAI2A,WNT11B,WNT7A,CALM3B,HRASB,CALM2,WNT7AA,HRAS,MAP2K2A,EDNRBA |
| Neural Crest Differentiation | CDH6,PRTG,HEY2,TFAP2B,MYB,HOXA1,CTBP2,MBP,OLIG1,LHX2 |
| Tyrosine metabolism | AOX1,HGD,COMTB,TPO,MIF,MAOB,TYRP1,DBH,GOT1,ADH2-1 |
| Metabolism | PPM1K,CPNE7,AMD2,SLC5A9,HS3ST4,Alb,CYP2K6,CYP2K17,UPP2,COX4I1 |
Protein Function
DCT has several biochemical functions, for example, copper ion binding,dopachrome isomerase activity,oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCT itself. We selected most functions DCT had, and list some proteins which have the same functions with DCT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | LOXL4,S100A12,PRND,S100V2,LOX,LOXL2,ATP7A,GPC1,AOC3,ANG |
| dopachrome isomerase activity | MIF,DDT |
| oxidoreductase activity | DEGS2,DIO3,RNLS,DHRS13A.1,FADS1,P4HA1A,CYP2C55,CYP4F14,SC5D,CYP2AA3 |
Interacting Protein
DCT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCT here. Most of them are supplied by our site. Hope this information will be useful for your research of DCT.
Resources
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References
- Ueno, M; Aoto, T; et al. Coupling of the radiosensitivity of melanocyte stem cells to their dormancy during the hair cycle. PIGMENT CELL & MELANOMA RESEARCH 27:-(2014).
- Filimon, A; Zurac, SA; et al. Value of dopachrome tautomerase detection in the assessment of melanocytic tumors. MELANOMA RESEARCH 24:219-236(2014).
