DCR-2
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Official Full Name
Dicer-2 -
Overview
RNA interference is an evolutionarily conserved gene silencing pathway in which the endonuclease, Dicer cleaves double stranded RNA into small interfering RNAs. Dicer is a multidomain protein related to the RNase III protein family. Dicer is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small interfering RNA (siRNA) component that represses gene expression. Dicer related RNA interference machinery is also involved in the formation of the heterochromatin structure in organisms such as yeast and higher vertebrate cells. In mammalian cells, both microRNAs (miRNAs) and small interfering RNAs (siRNAs) are thought to be loaded into the same RNA induced silencing complex (RISC), where they guide mRNA degradation or translation silencing depending on the complementarity of the target. Two transcript variants encoding the same protein have been identified. The Saccharomyces cerevisiae cell cycle regulator genes DCR2 and DCR1 appear to be involved in the initiation of DNA replication. It has been predicted that DCR2 might encode a protein with phosphoesterase activity. -
Synonyms
DCR-2;Dicer-2;cg6493;CG6493;Dcr;dcr-2;DCR-2;dcr2;Dcr2;DCR2;dic2;dicer;Dicer;DICER;dicer2;Dicer2;Dmel\CG6493;CG6493-PA;Dcr-2-PA;Dicer2;dicer;dicer 2
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Involved Pathway
DCR-2 involved in several pathways and played different roles in them. We selected most pathways DCR-2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DCR-2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
DCR-2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DCR-2 itself. We selected most functions DCR-2 had, and list some proteins which have the same functions with DCR-2. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
DCR-2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCR-2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCR-2.
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References
- Schuster, S; Zirkel, F; et al. A Unique Nodavirus with Novel Features: Mosinovirus Expresses Two Subgenomic RNAs, a Capsid Gene of Unknown Origin, and a Suppressor of the Antiviral RNA Interference Pathway. JOURNAL OF VIROLOGY 88:13447-13459(2014).
- Bronkhorst, AW; van Cleef, KWR; et al. A dsRNA-binding protein of a complex invertebrate DNA virus suppresses the Drosophila RNAi response. NUCLEIC ACIDS RESEARCH 42:12237-12248(2014).
