DAZ4
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Official Full Name
deleted in azoospermia 4 -
Overview
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
DAZ4;deleted in azoospermia 4;deleted in azoospermia protein 4;pDP1680;pDP1681
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DAZ4-11835H | Recombinant Human DAZ4, GST-tagged | E.coli | Human | GST | 1-343a.a. | |
| DAZ4-2356H | Recombinant Human DAZ4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DAZ4-7070HCL | Recombinant Human DAZ4 293 Cell Lysate | HEK293 | Human | Non |
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| DAZ4-2542HF | Recombinant Full Length Human DAZ4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 390 amino acids |
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| DAZ4-4134H | Recombinant Human DAZ4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
DAZ4 involved in several pathways and played different roles in them. We selected most pathways DAZ4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DAZ4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DAZ4 has several biochemical functions, for example, RNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAZ4 itself. We selected most functions DAZ4 had, and list some proteins which have the same functions with DAZ4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | PRKG1A,HNRNPA3,RAB3DA,RBM14A,MAP2K4B,G3BP2,SRSF6B,NSFB,ARL4AA,ABCG2C |
| RNA binding | RC3H2,MOV10B.1,RBM12B2,RBM48,RBM18,RPL11,EIF4E1C,ASCC1,C14orf166,DOM3Z |
Interacting Protein
DAZ4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAZ4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAZ4.
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