CYP2C18
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Official Full Name
cytochrome P450, family 2, subfamily C, polypeptide 18 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CYP2C18;cytochrome P450, family 2, subfamily C, polypeptide 18;CYP2C17, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 18;cytochrome P450 2C18;CPCI;CYP2C;P450IIC17;CYP2C 18;(S) mephenytoin hydroxylase associated cytochrome P450;CYP2C17;CYPIIC18;Cytochrome P450 family 2 subfamily C polypeptide 18;Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 17;Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 18;Flavoprotein linked monooxygenase;Microsomal monooxygenase;Unspecific monooxygenase;cytochrome P450-6B/29C;flavoprotein-linked monooxygenase;(S)-mephenytoin hydroxylase associated cytochrome P450;cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17;cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18;P450-6B/29C
Recombinant Proteins
- Rhesus macaque
- Chicken
- Human
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
CYP2C18 involved in several pathways and played different roles in them. We selected most pathways CYP2C18 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FOXA1 transcription factor network | DSCAM,AP1B1,POU2F1,NFIB,CEBPB,FOXA1,NRIP1,NFIC,CC10,TFF1 |
| Biological oxidations | CYP2R1,ABHD14B,FDXR,BPNT1,CYP27B1,CYP2V1,CYP2D6,UGT1B5,CYP2U1,CYP3C1 |
| Phase 1 - Functionalization of compounds | CYP2K17,CYP2Y3,CYP2K16,CYP27B1,CYP46A1,ADH8B,CYP3C4,CYP4T8,CYP2K19,CYP2AD3 |
| Chemical carcinogenesis | CYP3A43,CYP2C19,GSTM1,SULT1A2,GSTO2,ADH1,CYP3A4,CYP2A13,AKR1C2,GSTA1 |
| Metabolic pathways | ACOT5,MGAT4C,GPIA,LCLAT1,HMGCR,PTGIS,ITPKC,CYP2R1,B3GNT3,CYP11B2 |
| Cytochrome P450 - arranged by substrate type | CYP3A4,CYP3A7,CYP2K18,FDX1,CYP27A1,CYP2C8,CYP27B1,CYP4F12,CYP51A1,FDXR |
| Metabolism | MED20,ABCA1,GLS2B,NDUFAF6,MOCOS,ABHD4,SLC25A32A,MED23,FAM213B,GPAT2 |
| Retinol metabolism | RDH12,CYP26B1,UGT1A6B,CYP4A14,UGT2A2,UGT1A3,UGT1A1,CYP2C54,DGAT1,CYP2C39 |
Protein Function
CYP2C18 has several biochemical functions, for example, arachidonic acid epoxygenase activity,aromatase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C18 itself. We selected most functions CYP2C18 had, and list some proteins which have the same functions with CYP2C18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2D6,CYP2X7,CYP2A12,CYP1A,CYP2K18,CYP2P9,CYP2P6,CYP2X10.2,CYP2P8,CYP2A13 |
| monooxygenase activity | FMO1,CYP2X9,TPH1A,CYP2AA7,CYP20A1,CYP2C70,CYP4T8,CYP2K18,PTGIS,CYP2C19 |
| oxygen binding | HBBE2,CYP2AA2,CYP2P8,MB,BA1,CYP2X10.2,CYP2J2,HBBE1.1,HBA-X,CYP2A7 |
| iron ion binding | CYP2AA2,CYP1A4,CYP1A2,PHF2,CYP2A6,HIF1AN,SC4MOL,FAM125B,CYP2C39,LEPREL2 |
| arachidonic acid epoxygenase activity | CYP2B19,CYP2AA3,CYP2P7,CYP2D26,CYP2A13,CYP2P9,CYP2V1,CYP4F12,CYP2C37,CYP2A4 |
| heme binding | CYP2A7,CYP4F22,CYP2A6,CYP4F3,CYP4T8,HBB-Y,CYP2B19,HBM,CYP2AD2,TPO |
| aromatase activity | CYP2D10,CYP2A12,CYP2C37,CYP2S1,CYP2A7,CYP2J2,CYP4X1,CYP4Z1,CYP2A13,CYP2F1 |
| steroid hydroxylase activity | CYP2E1,CYP2J5,CYP2AD6,CYP1A1,CYP46A1.3,CYP21A2,CYP2P8,CYP2A13,CYP2P9,CYP2D6 |
Interacting Protein
CYP2C18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C18.
A2M;SDC2;ECSIT
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References
- Tsuchida, T; Zheng, YW; et al. The Development of Humanized Liver With Rag1 Knockout Rats. TRANSPLANTATION PROCEEDINGS 46:1191-1193(2014).
- Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).
