CYP27B1
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Official Full Name
cytochrome P450, family 27, subfamily B, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. -
Synonyms
CYP27B1;cytochrome P450, family 27, subfamily B, polypeptide 1;cytochrome P450, subfamily XXVIIB (25 hydroxyvitamin D 1 alpha hydroxylase), polypeptide 1 , PDDR, VDD1;25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial;1alpha(OH)ase;25 Hydroxyvita
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- T7
- Non
- Avi
- Fc
Involved Pathway
CYP27B1 involved in several pathways and played different roles in them. We selected most pathways CYP27B1 participated on our site, such as Biological oxidations,Cytochrome P450 - arranged by substrate type,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP27B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phase 1 - Functionalization of compounds | CYP46A1,CYP3A7-CYP3AP1,CYP8B2,CYP2N13,ADH8B,ADH8A,CYP2AD6,CYP4T8,CYP26A1,CES1 |
| Nuclear receptors in lipid metabolism and toxicity | CYP26A1,RARG,CYP24A1,RARGA,NR1I2,NR1I3,ABCC2,VDRB,RARGB |
| Metabolism | SULT1C2,GLTPA,AK7A,PNP5B,ACOT9.1,CPNE3,NUDT5,CD320,NUBP1,ACSM1 |
| Metabolism of lipids and lipoproteins | CRAT,CHAT,NEU3,YY2,STARD5,GLTPD1,MED18,AKR1C6,ACAD11,CYP46A1 |
| Metabolism of steroid hormones and vitamin D | HSD17B11,CYP24A1,AKR1B15,PPP1R2,STARD5,GC,CYP2R1 |
| Biological oxidations | CYP2C19,CYP4F22,CYP1A1,SULT1ST6,GLYATL2,CYP2K22,ADH8B,CYP11B2,CYP4F12,FDXR |
| Metabolic pathways | DHRS3B,AMD1,MAT2AA,GMPPA,GLS,PTGS1,UROS,PYCR1A,OGDHA,MDH1 |
| Cytochrome P450 - arranged by substrate type | CYP2K8,CYP2C18,CYP27A1,CYP2S1,CYP2K22,CYP2K19,CYP11A1,CYP19A1,CYP2AD2,CYP2K18 |
Protein Function
CYP27B1 has several biochemical functions, for example, calcidiol 1-monooxygenase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP27B1 itself. We selected most functions CYP27B1 had, and list some proteins which have the same functions with CYP27B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | CYP2K22,CYP4A12A,CYP20A1,CYP2B19,OGFOD3,ALOX8,HBAA,CYP2AD6,HBE,PHF8 |
| calcidiol 1-monooxygenase activity | IRGM1 |
| heme binding | PTGES2,CYP3C1,CYP2P7,CYP2J5,HBG1,HBAE1,CYP1A2,HBB-B2,TDO2A,CYP8B1 |
Interacting Protein
CYP27B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP27B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP27B1.
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References
- Girgis, CM; Mokbel, N; et al. The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers. ENDOCRINOLOGY 155:3227-3237(2014).
- Rolf, L; Muris, AH; et al. Vitamin D effects on B cell function in autoimmunity. STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES I 1317:84-91(2014).
