CYP27B1

  • Official Full Name

    cytochrome P450, family 27, subfamily B, polypeptide 1
  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
  • Synonyms

    CYP27B1;cytochrome P450, family 27, subfamily B, polypeptide 1;cytochrome P450, subfamily XXVIIB (25 hydroxyvitamin D 1 alpha hydroxylase), polypeptide 1 , PDDR, VDD1;25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial;1alpha(OH)ase;25 Hydroxyvita

Recombinant Proteins

  • Rhesus macaque
  • Rat
  • Human
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • T7
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP27B1-1142R Recombinant Rhesus monkey CYP27B1 Protein, His-tagged Mammalian Cells Rhesus macaque His
CYP27B1-1722R Recombinant Rat CYP27B1 Protein Mammalian Cells Rat His
CYP27B1-2254H Recombinant Human CYP27B1 Protein, GST-tagged Wheat Germ Human GST
CYP27B1-4157M Recombinant Mouse CYP27B1 Protein Mammalian Cells Mouse His
CYP27B1-8069H Recombinant Human CYP27B1 protein, His & T7-tagged E.coli Human His&T7 Asp256~Arg508
Cyp27b1-8070M Recombinant Mouse Cyp27b1 protein, His & T7-tagged E.coli Mouse His&T7 Asp258~Phe504
Cyp27b1-8071R Recombinant Rat Cyp27b1 protein, His & T7-tagged E.coli Rat His&T7 Asp251~Asp500
CYP27B1-856H Recombinant Human CYP27B1 Protein, His-tagged E.coli Human His
CYP27B1-7118HCL Recombinant Human CYP27B1 293 Cell Lysate HEK293 Human Non
CYP27B1-1381R Recombinant Rat CYP27B1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CYP27B1-1381R-B Recombinant Rat CYP27B1 Protein Pre-coupled Magnetic Beads HEK293 Rat
CYP27B1-1916H Recombinant Human CYP27B1 Protein (Asp256-Arg508), N-His tagged E.coli Human His Asp256-Arg508
CYP27B1-2132M Recombinant Mouse CYP27B1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CYP27B1-2132M-B Recombinant Mouse CYP27B1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CYP27B1-2339HF Recombinant Full Length Human CYP27B1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 508 amino acids
Cyp27b1-2791M Recombinant Mouse Cyp27b1 protein, His-tagged E.coli Mouse His 1-507aa
CYP27B1-967R Recombinant Rhesus Macaque CYP27B1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYP27B1-967R-B Recombinant Rhesus Macaque CYP27B1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CYP27B1 involved in several pathways and played different roles in them. We selected most pathways CYP27B1 participated on our site, such as Biological oxidations,Cytochrome P450 - arranged by substrate type,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP27B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phase 1 - Functionalization of compounds CYP46A1,CYP3A7-CYP3AP1,CYP8B2,CYP2N13,ADH8B,ADH8A,CYP2AD6,CYP4T8,CYP26A1,CES1
    Nuclear receptors in lipid metabolism and toxicity CYP26A1,RARG,CYP24A1,RARGA,NR1I2,NR1I3,ABCC2,VDRB,RARGB
    Metabolism SULT1C2,GLTPA,AK7A,PNP5B,ACOT9.1,CPNE3,NUDT5,CD320,NUBP1,ACSM1
    Metabolism of lipids and lipoproteins CRAT,CHAT,NEU3,YY2,STARD5,GLTPD1,MED18,AKR1C6,ACAD11,CYP46A1
    Metabolism of steroid hormones and vitamin D HSD17B11,CYP24A1,AKR1B15,PPP1R2,STARD5,GC,CYP2R1
    Biological oxidations CYP2C19,CYP4F22,CYP1A1,SULT1ST6,GLYATL2,CYP2K22,ADH8B,CYP11B2,CYP4F12,FDXR
    Metabolic pathways DHRS3B,AMD1,MAT2AA,GMPPA,GLS,PTGS1,UROS,PYCR1A,OGDHA,MDH1
    Cytochrome P450 - arranged by substrate type CYP2K8,CYP2C18,CYP27A1,CYP2S1,CYP2K22,CYP2K19,CYP11A1,CYP19A1,CYP2AD2,CYP2K18

    Protein Function

    CYP27B1 has several biochemical functions, for example, calcidiol 1-monooxygenase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP27B1 itself. We selected most functions CYP27B1 had, and list some proteins which have the same functions with CYP27B1. You can find most of the proteins on our site.

    Function Related Protein
    iron ion binding CYP2K22,CYP4A12A,CYP20A1,CYP2B19,OGFOD3,ALOX8,HBAA,CYP2AD6,HBE,PHF8
    calcidiol 1-monooxygenase activity IRGM1
    heme binding PTGES2,CYP3C1,CYP2P7,CYP2J5,HBG1,HBAE1,CYP1A2,HBB-B2,TDO2A,CYP8B1

    Interacting Protein

    CYP27B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP27B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP27B1.

    Resources

    References

    • Girgis, CM; Mokbel, N; et al. The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers. ENDOCRINOLOGY 155:3227-3237(2014).
    • Rolf, L; Muris, AH; et al. Vitamin D effects on B cell function in autoimmunity. STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES I 1317:84-91(2014).

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