CYP26A1
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Official Full Name
cytochrome P450, family 26, subfamily A, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. -
Synonyms
CYP26A1;cytochrome P450, family 26, subfamily A, polypeptide 1;cytochrome P450, subfamily XXVIA, polypeptide 1;cytochrome P450 26A1;CP26;CYP26;P450RAI;P450RAI1;hP450RAI;cytochrome P450RAI;retinoic acid 4-hydroxylase;P450, retinoic acid-inactiva
Recombinant Proteins
- Chicken
- Rhesus macaque
- Mouse
- Human
- Zebrafish
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- His
- His&T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CYP26A1 involved in several pathways and played different roles in them. We selected most pathways CYP26A1 participated on our site, such as Adipogenesis,Biological oxidations,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP26A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phase 1 - Functionalization of compounds | CYP3C4,CES1,CYP2AD3,ADH8A,CYP2F1,CYP2AD6,CYP2C18,CYP2V1,CYP2K19,CYP4F12 |
| Adipogenesis | MIXL1,RETN,FRZB,AHR,DVL1,E2F4,NR1H3,KLF6A,GATA2A,NRIP1 |
| Cytochrome P450 - arranged by substrate type | CYP46A1,FAM84B,CYP2K6,CYP2R1,CYP2S1,CYP2AD3,CYP2K17,CYP3A5,CYP2C9,CYP2C19 |
| Metabolism | PPP1R2,SLC46A1,CKMB,HPSE,ARSD,MED22,GGTLC1,ZDHHC21,NFYAL,SULT1ST5 |
| RA biosynthesis pathway | ALDH8A1,RDH14B,DHRS3,AKR1C21,DHRS3A,ADH8A,RDH7,RDH14,ADH8B,AKR1C6 |
| Biological oxidations | CES1,CYP2S1,CYP2R1,SLC35D1A,CYP51A1,DPEP2,FAM84B,CYP2V1,COMT,SULT1ST5 |
| Metabolic pathways | HSD17B12,CYP2S1,POLR2A,UROS,COX4I2,PLCG1,TPH1A,KYNU,DCT,TM7SF2 |
| Nuclear receptors in lipid metabolism and toxicity | NR1I2,ABCC2,RARGB,NR1I3,CYP27B1,VDRB,CYP24A1,RARGA,RARG |
Protein Function
CYP26A1 has several biochemical functions, for example, heme binding,iron ion binding,oxygen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP26A1 itself. We selected most functions CYP26A1 had, and list some proteins which have the same functions with CYP26A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| retinoic acid 4-hydroxylase activity | CYP26B1 |
| iron ion binding | CYP2D26,CH25H,HBB-BH1,CYP3C1,FAXDC2,OGFOD1,EGLN1,TPH1A,CYP21A2,CYP2C70 |
| retinoic acid binding | UGT1A3,CYP26B1,CRABP1A,UGT1A9,NR2F2,SERPINA5,UGT1A1,UGT1A2,CRABP1B,UGT1A7 |
| oxygen binding | HBBE3,CYP2K16,HBB-BH1,CYP2A7,CYP2AD2,CYP2A4,CYP2D26,CYP2A13,HBE,CYP2C38 |
| heme binding | CYP26C1,GUCY1B3,CYP1A2,CYP3C1,CYP46A1.1,CYP4F18,CYP2C38,FECH,CYP27C1,PTGS2 |
Interacting Protein
CYP26A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP26A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP26A1.
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References
- Brown, GT; Cash, BG; et al. The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer. PLOS ONE 9:-(2014).
- Liu, HY; Chao, HH; et al. Regulation of cyp26a1 on Th17 cells in mouse peri-implantation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:455-467(2014).
