CYBA

  • Official Full Name

    cytochrome b-245, alpha polypeptide

  • Overview

    Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

  • Synonyms

    CYBA;cytochrome b-245, alpha polypeptide;p22-PHOX;cytochrome b-245 light chain;p22phox;cytochrome b light chain;p22 phagocyte B-cytochrome;cytochrome b(558) alpha chain;cytochrome b558 subunit alpha;cytochrome b(558) alpha-subunit;cytochrome b, alpha polypeptide;flavocytochrome b-558 alpha polypeptide;neutrophil cytochrome b 22 kDa polypeptide;superoxide-generating NADPH oxidase light chain subunit

Recombinant Proteins

  • Zebrafish
  • Rat
  • Human
  • Dictyostelium Discoideum
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E.coli
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYBA-10857Z Recombinant Zebrafish CYBA Mammalian Cells Zebrafish His
CYBA-1706R Recombinant Rat CYBA Protein Mammalian Cells Rat His
CYBA-2221H Recombinant Human CYBA Protein, GST-tagged Wheat Germ Human GST
CYBA-7139HCL Recombinant Human CYBA 293 Cell Lysate HEK293 Human Non
CYBA-1365R Recombinant Rat CYBA Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CYBA-1365R-B Recombinant Rat CYBA Protein Pre-coupled Magnetic Beads HEK293 Rat
CYBA-2386HF Recombinant Full Length Human CYBA Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 254 amino acids
RFL34531DF Recombinant Full Length Dictyostelium Discoideum Superoxide-Generating Nadph Oxidase Light Chain Subunit(Cyba) Protein, His-Tagged E.coli Dictyostelium Discoideum His Full L. Full Length (1-118)

    Involved Pathway

    CYBA involved in several pathways and played different roles in them. We selected most pathways CYBA participated on our site, such as Adaptive Immune System,Antigen processing-Cross presentation,Class I MHC mediated antigen processing &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYBA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class I MHC mediated antigen processing &amp TRIM50,WWP1,TRIM11,SEC23A,TRIM69,UBE2E3,NPEPPS,ASB2,WSB1,UBE2V2
    presentation ERAP1,RNF111,LRR1,TRIM39,FBXO44,RNF220,RNF6,RNF138,HECTD3,KLHL20
    Cross-presentation of particulate exogenous antigens (phagosomes) CYBB
    Osteoclast differentiation PPARG,PIK3R5,CALCR,PIK3CG,MITF,GAB2,AKT2,NOX3,MAPK8,NCF4
    Leukocyte transendothelial migration CLDN16,CLDN14,PIK3R3,CLDN7,RHOA,JAM2,MAPK13,NCF2,CLDN4,ROCK2
    Immune System SUGT1,UBR1,CFHL1,DDOST,KIF4A,RNF182,RNF123,TXN,RAP1GAP2B,BST2
    Leishmaniasis H2-AA,STAT1,ITGB1,TGFB3,Itgam&Itgb2,TGFB1,FCGR4,HLA-DRB5,HLA-DOA,CR1
    Adaptive Immune System CREB1,TRIM69,RNF41,LILRB2,CD300LF,MICA,NRG3,AP1M2,KLRF1,RNF6
    Antigen processing-Cross presentation CYBB,CTSL1,FCGR1B,CD207,CTSL2,SEC61B,CTSS

    Protein Function

    CYBA has several biochemical functions, for example, SH3 domain binding,electron carrier activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYBA itself. We selected most functions CYBA had, and list some proteins which have the same functions with CYBA. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding SH3BGRL2,FMN1,MYPN,TOM1L1,NOXA1,ARHGAP17,PTTG2,ADAM19,GRIK5,ARHGAP27
    contributes_to superoxide-generating NADPH oxidase activity CYBB
    electron carrier activity GRX2,ALDH4A1,PTGES2,DERL3,UGDH,COX7A2A,LOXL2,ACOX3,AKR1B1,ACADL
    protein heterodimerization activity EFHA1,VAPB,ATF3,BCL2A1A,ADD2,MID1,TAF8,CUL3,YWHAH,CHRAC1
    heme binding CYP51,CYP2C55,CYP7A1A,GUCY1B3,HBB-BH1,CYP2AA9,MB,CYP20A1,CYP2V1,CYP2AA6
    metal ion binding CMC1,SOBPA,LIAS,PON2,KCNIP1B,BTR12,POLM,SUCLA2,ZNF143B,DEAF1
    protein binding PTS,RG9MTD1,RAB9B,APIP,DCTN4,AGO2,PSMD14,ERAL1,NKRF,THOC7

    Interacting Protein

    CYBA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYBA here. Most of them are supplied by our site. Hope this information will be useful for your research of CYBA.

    NCF1;NOXO1;MDFI;NCF4;CPT1A;RCHY1;MYC

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