CUL4B
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Official Full Name
cullin 4B -
Overview
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CUL4B;cullin 4B;cullin-4B;CUL-4B;SFM2;MRXSC;MRXHF2;MRXS15;KIAA0695;DKFZp686F1470
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- His
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CUL4B-11705H | Recombinant Human CUL4B, His-tagged | E.coli | Human | His | 1-195a.a. | |
| CUL4B-173H | Recombinant Human CUL4B protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CUL4B-6599Z | Recombinant Zebrafish CUL4B | Mammalian Cells | Zebrafish | His |
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| CUL4B-7181HCL | Recombinant Human CUL4B 293 Cell Lysate | HEK293 | Human | Non |
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| CUL4B-1120HFL | Recombinant Full Length Human CUL4B protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| CUL4B-2083M | Recombinant Mouse CUL4B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CUL4B-2083M-B | Recombinant Mouse CUL4B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Cul4b-2378M | Recombinant Mouse Cul4b Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| CUL4B-4207H | Recombinant Human CUL4B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| CUL4B-670HF | Recombinant Full Length Human CUL4B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 913 amino acids |
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Involved Pathway
CUL4B involved in several pathways and played different roles in them. We selected most pathways CUL4B participated on our site, such as Nucleotide excision repair,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | POLE,RPA2,GPS1,COPS7B,GTF2H2C_2,RAD23AB,BIVM-ERCC5,ACTR5,RBX1,YY1A |
| Ubiquitin mediated proteolysis | NEDD4L,UBE2Z,DET1,HERC3,KLHL9,BIRC7,PIAS4A,UBE4A,TCEB2,UBE2G1A |
Protein Function
CUL4B has several biochemical functions, for example, contributes_to damaged DNA binding,protein binding,contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL4B itself. We selected most functions CUL4B had, and list some proteins which have the same functions with CUL4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EDC3,DHX16,ARMCX5,GRIP1,PURA,EIF3L,SLC30A2,NAPB,TRAPPC5,CDC14B |
| ubiquitin protein ligase binding | FAF1,TRIOBP,PIAS4,TRIB1,RAD18,SMAD2,DNM1L,CUL5,CDC34A,POU5F1 |
| contributes_to damaged DNA binding | DDB2,NBN,DDB1 |
| contributes_to ubiquitin protein ligase activity | FBXL12,CUL2,FBXL15,MED12,FBXL17,CUL1,FBXL3,CUL5,CUL1A,FBXL3B |
Interacting Protein
CUL4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL4B here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL4B.
DDB1;COPS5
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