CUL4A
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Official Full Name
cullin 4A -
Overview
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins. -
Synonyms
CUL4A;cullin 4A;cullin-4A;CUL-4A;OTTHUMP00000018753;OTTHUMP00000018754
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Insect Cell
- Sf21 insect cells
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- E.coli
- N-His-Avi
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
CUL4A involved in several pathways and played different roles in them. We selected most pathways CUL4A participated on our site, such as Nucleotide excision repair,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | COPS5,COPS3,PPIE,GTF2H5,POLE4,POLE2,GTF2H1,POLD4,CUL4B,KIAA1530 |
| Ubiquitin mediated proteolysis | ANAPC5,MDM2,UBE2IA,ANAPC2,FANCL,SKP1,HUWE1,DET1,FZR1A,UBE2D1B |
Protein Function
CUL4A has several biochemical functions, for example, protein binding,contributes_to ubiquitin protein ligase activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL4A itself. We selected most functions CUL4A had, and list some proteins which have the same functions with CUL4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin protein ligase activity | FBXL15,CUL1,FBXL14A,FBXL4,CUL5A,CUL1A,FBXL3,FBXL18,CUL4B,FBXL14B |
| protein binding | GEMIN4,DFFA,BICC1,KRTAP5-9,RASGRP3,MCM8,LDHD,CEP85,SMARCA4,TNFAIP8 |
| ubiquitin protein ligase binding | CCT2,SNCAIP,PRKACB,RNF40,CUL9,DERL1,NFKBIA,PRDX6,ATP6V0C,FAF2 |
Interacting Protein
CUL4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL4A here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL4A.
DDB1;CAND1;DDB2;Dtl;Ddb1;COPS5;RBBP5
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