CTTN
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Official Full Name
cortactin -
Overview
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. -
Synonyms
CTTN;cortactin;EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma associated (p80/85 src substrate);src substrate cortactin;amplaxin;1110020L01Rik;oncogene EMS1;ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/8
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Rat
- Human
- Chicken
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- Sf9 Insect Cell
- Mamanlian cells
- HEK293T
- His
- GST
- Myc&DDK
- Flag
- Non
- His&Fc&Avi
Involved Pathway
CTTN involved in several pathways and played different roles in them. We selected most pathways CTTN participated on our site, such as Tight junction,Bacterial invasion of epithelial cells,Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Shigellosis | RIPK2,U2AF1L4,UBE2D2,ACTG1,MAPK8,PFN1,ROCK2,PFN2,SRC,ROCK1 |
| Proteoglycans in cancer | MSN,PIK3R2,PLAUR,HPSE,ITGAV,PRKCA,TRP53,PLCG2,MAPK1,PIK3R1 |
| Tight junction | ACTN3A,MAGI3,ACTB,CLDNH,KRAS,CLDN4,CLDN10A,CLDN11B,VAPAL,EPB41L2 |
| Pathogenic Escherichia coli infection | TUBA4A,RHOA,TUBB1,CD14,ACTB,TUBAL3,CDH1,KRT18,YWHAZ,EZR |
| Bacterial invasion of epithelial cells | PIK3CB,SEPT12,DOCK1,WAS,GAB1,SEPT11,ITGB1,PIK3R2,ARPC3,PIK3CG |
Protein Function
CTTN has several biochemical functions, for example, profilin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTTN itself. We selected most functions CTTN had, and list some proteins which have the same functions with CTTN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| profilin binding | DIAPH1,CYFIP1,RHOQ,FMNL1,WIPF1,HTT,EVL,DIAP1,PCLO,VASP |
| protein binding | IL12B,TAF1C,SALL2,NVL,SMCR7,CD1B,PRCC,KIF5C,RAMP2,TULP1 |
Interacting Protein
CTTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTTN here. Most of them are supplied by our site. Hope this information will be useful for your research of CTTN.
ASAP1;DNM2;GRB2;Kcnma1;ARRB2
Resources
Research Area
Adherens Junction Proteins in Endothelial CellsAdherens Junction Proteins in VSMC
Mesenchymal Cells and EMT
Invadopodia Molecules
Matrix Remodeling Molecules
Related Services
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References
