CTNS
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Official Full Name
cystinosin, lysosomal cystine transporter -
Overview
This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. -
Synonyms
CTNS;cystinosin, lysosomal cystine transporter;cystinosis, nephropathic;cystinosin;CTNS LSB;PQLC4;CTNS-LSB
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Bovine
- Mus musculus
- Dictyostelium Discoideum
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
CTNS involved in several pathways and played different roles in them. We selected most pathways CTNS participated on our site, such as Lysosome,Miscellaneous transport and binding events,SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | GNPTG,ATP6AP1B,CTSG,IDS,AP3S1,PLA2G15,PPT1,IDUA,ATP6V0CA,CLTCB |
| Miscellaneous transport and binding events | AZGP1,ANKHB,ANKH,ANKHA,PIP,MRS2,NIPA1,ADD3B,MAGT1,MMGT1 |
| SLC-mediated transmembrane transport | SLC38A3A,LCN1,SLC5A6B,SLC35A1,SLC26A3,SLC35A3,SLC24A5,SLC26A3.1,SLC41A1,SLC24A6 |
| Transmembrane transport of small molecules | SLC22A7,SLCO2A1,ABCG4B,FXYD3,CLCN4-2,SLC30A1B,ANO5,TRPC5,CCC2,TSC22D3 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC6A20,SLC7A10,SLC9A6A,SLC38A5B,SLC24A5,SLC43A2B,SLC4A1A,SLC26A3.1,SLC6A18,SLC4A3 |
Protein Function
CTNS has several biochemical functions, for example, L-cystine transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNS itself. We selected most functions CTNS had, and list some proteins which have the same functions with CTNS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-cystine transmembrane transporter activity | SLC1A4,SLC3A1 |
Interacting Protein
CTNS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNS here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNS.
Resources
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References
- Taranta, A; Petrini, S; et al. Distribution of cystinosin-LKG in human tissues. HISTOCHEMISTRY AND CELL BIOLOGY 138:351-363(2012).
- Simpson, J; Nien, CJ; et al. Quantitative in vivo and ex vivo confocal microscopy analysis of corneal cystine crystals in the Ctns(-/-) knockout mouse. MOLECULAR VISION 17:2212-2220(2011).
