CTIF
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Official Full Name
CBP80/20-dependent translation initiation factor -
Overview
CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that;binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous;editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing;mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with;cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes;in the cytoplasm (Kim et al., 2009 (PubMed 19648179)). -
Synonyms
CTIF;CBP80/20-dependent translation initiation factor;KIAA0427;Gm672;Hypothetical protein LOC9811;Uncharacterized protein KIAA0427
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CTIF-903HCL | Recombinant Human CTIF cell lysate | Human | Non |
|
Involved Pathway
CTIF involved in several pathways and played different roles in them. We selected most pathways CTIF participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CTIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CTIF has several biochemical functions, for example, RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTIF itself. We selected most functions CTIF had, and list some proteins which have the same functions with CTIF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | DNAJC17,RPL11,TRNAU1APB,PPRC1,SFSWAP,MCTS2,SRSF1,HNRNPUL1,EIF4E2RS1,NANOS1 |
| protein binding | ADAM8,ERGIC1,CBR2,NLGN3,TKT,SELENBP1,SAP18,DTX3L,TINAGL1,NEFM |
Interacting Protein
CTIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTIF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTIF.
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References
- Choe, J; Ryu, I; et al. eIF4AIII enhances translation of nuclear cap-binding complex-bound mRNAs by promoting disruption of secondary structures in 5 ' UTR. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E4577-E4586(2014).
- Shatsky, IN; Dmitriev, SE; et al. Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 49:164-177(2014).
