CTDP1
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Official Full Name
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -
Overview
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] -
Synonyms
CTDP1;CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1;FCP1;CCFDN;RNA polymerase II subunit A C-terminal domain phosphatase;serine phosphatase FCP1a;TFIIF-associating CTD phosphatase 1;CTD of POLR2A, phosphatase of, subunit 1;transcription factor IIF-associating CTD phosphatase 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CTDP1-2059H | Recombinant Human CTDP1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CTDP1-4016M | Recombinant Mouse CTDP1 Protein | Mammalian Cells | Mouse | His |
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| CTDP1-861Z | Recombinant Zebrafish CTDP1 | Mammalian Cells | Zebrafish | His |
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| CTDP1-2046M | Recombinant Mouse CTDP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CTDP1-2046M-B | Recombinant Mouse CTDP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CTDP1-2204M | Recombinant Mouse CTDP1 Protein (178-341 aa), His-Myc-tagged | E.coli | Mouse | His&Myc | 178-341 aa |
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Involved Pathway
CTDP1 involved in several pathways and played different roles in them. We selected most pathways CTDP1 participated on our site, such as Abortive elongation of HIV-1 transcript in the absence of Tat,Disease,Formation of HIV elongation complex in the absence of HIV Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTDP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formation of the Early Elongation Complex | WHSC2,TH1L,SUPT5H,RDBP,SUPT4H1,COBRA1,GM3258,NELFE |
| Formation of RNA Pol II elongation complex | CCNT2B,SUPT16H,COBRA1,GM3258,WHSC2,SSRP1,TCEB3,PSTPIP2,TCEA1,CDK9 |
| Formation of HIV elongation complex in the absence of HIV Tat | CDK9,SUPT5H,COBRA1,SUPT4H1,RDBP,ELL,TH1L,TCEA1,SSRP1,WHSC2 |
| Formation of HIV-1 elongation complex containing HIV-1 Tat | ELL,TCEB3,SUPT4H1,TCEA1,RDBP,COBRA1,CDK9,SUPT5H,TH1L,SSRP1 |
| Abortive elongation of HIV-1 transcript in the absence of Tat | COBRA1,SUPT5H,TH1L,RDBP,SUPT4H1,WHSC2 |
| Formation of the HIV-1 Early Elongation Complex | SUPT5H,COBRA1,SUPT4H1,WHSC2,TH1L,RDBP |
| Disease | COBRA1,SSRP1,KPNA5,CTBP1,OPN1LW,BANF1,VPS37A,AP1B1,TICAM1,RPL35 |
| Gene Expression | RORAA,YBX1,TAF1A,SUZ12,SMG8,TNKS1BP1,ADAR,MTF2,ELAVL1,NR5A1A |
Protein Function
CTDP1 has several biochemical functions, for example, CTD phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTDP1 itself. We selected most functions CTDP1 had, and list some proteins which have the same functions with CTDP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF433,DUSP13,KIAA1530,E2F7,GTF3C5,UHRF1,TAC3,RARB,APPL2,SNX20 |
| CTD phosphatase activity | PPM1M,CTDSPLB,CTDSP1,CTDSP2,CTDSPL,SSU72,CTDSPLA,RPAP2 |
Interacting Protein
CTDP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTDP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTDP1.
PRMT5;POLR2B;ERH;STK38;POLR2A;WDR77;tktA;eno;Setdb1;LTN1;ETS2;CDK8;POLR2F;POLR2G
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