CTCFL
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Official Full Name
CCCTC-binding factor (zinc finger protein)-like -
Overview
CCCTC-binding factor (CTCF) and its paralog, the Brother of the Regulator of Imprinted Sites (BORIS), are highly conserved transcription factors that regulate transcriptional activation and repression, insulator function, and imprinting control regions (I -
Synonyms
CTCFL;CCCTC-binding factor (zinc finger protein)-like;transcriptional repressor CTCFL;BORIS;cancer/testis antigen 27;CT27;dJ579F20.2;HMG-1L1;CTCF paralog;CTCF-like protein;BORIS-like protein;zinc finger protein CTCF-T;brother of the regulator
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- Yeast
- E.coli
- GST
- Non
- His
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CTCFL-2058H | Recombinant Human CTCFL Protein, GST-tagged | Wheat Germ | Human | GST |
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| CTCFL-27664TH | Recombinant Human CTCFL | Wheat Germ | Human | Non | 101 amino acids |
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| CTCFL-4014M | Recombinant Mouse CTCFL Protein | Mammalian Cells | Mouse | His |
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| CTCFL-7212HCL | Recombinant Human CTCFL 293 Cell Lysate | HEK293 | Human | Non |
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| CTCFL-1372M | Recombinant Mouse CTCFL Protein (1-636 aa), His-tagged | Yeast | Mouse | His | 1-636 aa |
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| CTCFL-2044M | Recombinant Mouse CTCFL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CTCFL-2044M-B | Recombinant Mouse CTCFL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CTCFL-434M | Recombinant Mouse CTCFL Protein (1-636 aa), His-SUMO-tagged | E.coli | Mouse | His&SUMO | 1-636 aa |
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Involved Pathway
CTCFL involved in several pathways and played different roles in them. We selected most pathways CTCFL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CTCFL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CTCFL has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTCFL itself. We selected most functions CTCFL had, and list some proteins which have the same functions with CTCFL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NKX3-1,MLL1,LIG4,NR5A1,SNAPC4,TOX2,ZSCAN4C,DLX1A,PURBA,ARX |
| histone binding | HIST1H3C,NCL,TBL1X,ASF1A,L3MBTL2,SET,BRD1,UHRF1,UIMC1,HIST1H3A |
| sequence-specific DNA binding | HOXC12A,OTPB,LHX8,NR4A2A,HOXB1,NKX2.5,SPI1A,INSM1A,SCAND2P,ISL2 |
| transcription regulatory region DNA binding | TAF9,NKX3-1,H2AFY2,SALL1,FOXC1,CTCF,ZNF335,TFAP4,ATF3,ZNF567 |
| metal ion binding | PLEKHF2,CYP2D9,RAF1B,ZBTB22,Car2,GNAS,MTHFS,CSHL1,THOP1,IHHB |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | AKNA,PHOX2B,PDX1,PAX8,TBP,KCNA3,ELF1,SREBF1,NR3C1,NOBOX |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SRF,MYBL1,IRF1,EBF3A,CEBPA,SFPI1,PLSCR1,JUN,CAMTA1,KLF13 |
| protein binding | AP5Z1,MATK,HIST1H2AH,CNTF,ANXA2,LOXL3,MPPED2,SPOPL,MKI67,SLC16A3 |
Interacting Protein
CTCFL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTCFL here. Most of them are supplied by our site. Hope this information will be useful for your research of CTCFL.
b4dyc6_human;SGTA;STIP1;FKBP5;q53fc7_human;HSP90AB1;NUDCD3;UNC45B;NUDCD2;q96be0_human;AARSD1;q9hav2_human;STUB1;NUDC;ZDHHC17
Resources
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References
- Nikolic, T; Movita, D; et al. The DNA-binding factor Ctcf critically controls gene expression in macrophages. CELLULAR & MOLECULAR IMMUNOLOGY 11:58-70(2014).
- Hoivik, EA; Kusonmano, K; et al. Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. ONCOTARGET 5:1052-1061(2014).
