CTBP2
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Official Full Name
C-terminal binding protein 2 -
Overview
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3 untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. -
Synonyms
CTBP2;C-terminal binding protein 2;C-terminal-binding protein 2;ribeye;C terminal binding protein 2;CTBP2_HUMAN;OTTHUMP00000020699;OTTHUMP00000020700;OTTHUMP00000020701;OTTHUMP00000235908;OTTHUMP00000235909;OTTHUMP00000235910
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- T7
- GST
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
CTBP2 involved in several pathways and played different roles in them. We selected most pathways CTBP2 participated on our site, such as Chronic myeloid leukemia,Degradation of beta-catenin by the destruction complex,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | RARA,PTGS2,MET,CBL,VEGFA,AXIN2,GNA12,LEF1,SKP2,MAPK1 |
| Disease | ACAN,PSIP1,RPL35,OPN1MW,PPIA,KREMEN1,CPSF6,CCNC,SUPT4H1,NMT2 |
| Neural Crest Differentiation | PHOX2B,CDH6,MBP,PRTG,TCF4,DCT,OLIG3,GBX2,HEY2,TXLNB |
| Chronic myeloid leukemia | CBL,MAP2K2,RUNX1,MECOM,PTPN11,TGFB3,RAF1,SHC3,HDAC2,MDM2 |
| Notch signaling pathway | DTX2,RFNG,HER12,NCOR2,MFAP2,ADAM17A,TUBB3,CTBP2A,HDAC2,ADAM12 |
| Degradation of beta-catenin by the destruction complex | TLE4,CTBP1,TLE2,AES,TLE3,FAM123B,TLE3B,TLE1 |
| Diseases of signal transduction | CDK8,MYO18A,OPN1MW2,TRAT1,RBP4,CDC37,KREMEN2,RLBP1,HEYL,OPN1MW |
Protein Function
CTBP2 has several biochemical functions, for example, NADH binding,chromatin binding,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by CTBP2 itself. We selected most functions CTBP2 had, and list some proteins which have the same functions with CTBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | HOXD10,DNMT3B,SMAD2,MEIOB,MTA1,GATA5,SETD7,BAHD1,GATA6,NEUROG1 |
| retinoic acid receptor binding | HMGA1,PRAMEF1,CNOT1,PRAMEF6,ASXL1,NSD1,PRAMEF2,AASS,LRIF1,PRAMEF10 |
| protein homodimerization activity | KLHL7,TYW5,IDE,AMICA1,MTUS2,GRM6,GSTM3,MAP3K11,IL17F,TCF12 |
| protein binding | SRSF11,KIFAP3,CAMSAP1L1,PLDN,LAPTM5,ICAM1,DHPS,C19orf44,PTPRM,FAM131B |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD3B5,GPD1A,SDR42E1,GRHPRB,LDHBA,HSD3B6,MDH1AA,MDH1B,CTBP1,LDHBB |
| transcription coactivator activity | NFE2L3,GABPA,GATA3,CBFB,YY1,MED26,PRPF6,DDX5,TADA3,ATF2 |
| NADH binding | QDPR,CTBP2A,CTBP1 |
| transcription corepressor activity | NR0B2A,SSX4,HIPK2,LOXL2,NFKBIL2,TBL1XR1B,HEYL,BCL11A,PIAS1,HDAC3 |
Interacting Protein
CTBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTBP2.
TGIF1;IKZF1;RAI2;CCNH;FOXP2
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References
- Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).
- Muller, B; Butz, E; et al. The Rod Pathway of the Microbat Retina Has Bistratified Rod Bipolar Cells and Tristratified AII Amacrine Cells. JOURNAL OF NEUROSCIENCE 33:1014-1023(2013).
