CS
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Official Full Name
citrate synthase -
Overview
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. -
Synonyms
CS;citrate synthase;citrate synthase, mitochondrial;mitochondrial;CISY_HUMAN;citrate synthetase
Recombinant Proteins
- Human
- Pig
- Zebrafish
- Rat
- Mouse
- Cynomolgus
- E.coli
- Porcine Heart
- Mammalian Cell
- Wheat Germ
- Insect Cell
- Human Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- Non
- His
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CS involved in several pathways and played different roles in them. We selected most pathways CS participated on our site, such as 2-Oxocarboxylic acid metabolism,Biosynthesis of amino acids,Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with CS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Citric acid cycle (TCA cycle) | DLST |
| Metabolic pathways | ybaS,PIPOX,DNMT3,MTMR3,PYCR1A,POLR3D,LDHA,FUK,PPAP2D,EPT1 |
| Biosynthesis of antibiotics | AMDHD2,pykF,AK8,AK7,EHHADH,NME6,SDS,CYP51A1,ECHS1,LDHAL6A |
| Citrate cycle (TCA cycle) | SDHC,PC,IDH2,DLDH,PDHA2,IDH3G,PCK1,SDHB,ACO2,SUCLG2 |
| 2-Oxocarboxylic acid metabolism | NAGS |
| Carbon metabolism | ENO2,FH,ENO1B,PCXB,FH1,PFKM,PKMB,SUCLG2,DLAT,GPI |
| Glyoxylate and dicarboxylate metabolism | HAO2,GCSHA,MDH2,AGXTA,ANI_1_2390104,ACO1,AMT,PGP,DLDH,GCSHB |
| Biosynthesis of amino acids | PYCRL,CBS,BCAT2,PRPS1L1,ACO1,ASL,PRPS2,GAPDH,THA1,GPT2L |
Protein Function
CS has several biochemical functions, for example, citrate (Si)-synthase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CS itself. We selected most functions CS had, and list some proteins which have the same functions with CS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SNRPB,METAP2,NOP58,MRPS35,CCDC47,EXOSC6,NUCKS1,MRPS7,EXOSC8,SF3A3 |
Interacting Protein
CS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CS here. Most of them are supplied by our site. Hope this information will be useful for your research of CS.
SGK1;MCC;CHM;HLA-B;USP11;EIF6;ARF6;TAB2;TRAF6;ere_dna;ATF2;CLPP
Resources
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References
- Zhang, SX; Zhang, F; et al. Hematopoietic Stem Cell Capture and Directional Differentiation into Vascular Endothelial Cells for Metal Stent-Coated Chitosan/Hyaluronic Acid Loading CD133 Antibody. TISSUE ENGINEERING PART A 21:1173-1183(2015).
- Langereis, EJ; van Vlies, N; et al. Biomarker responses correlate with antibody status in mucopolysaccharidosis type I patients on long-term enzyme replacement therapy. MOLECULAR GENETICS AND METABOLISM 114:129-137(2015).
