CRAT
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Official Full Name
carnitine O-acetyltransferase -
Overview
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Alternate splicing results in multiple transcript variants; additional transcript variants have been described, but their biological validity has not been determined. -
Synonyms
CRAT;carnitine O-acetyltransferase;carnitine acetyltransferase;CAT1;Carnitine acetylase;Carnitine O acetyltransferase;CAT
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CRAT involved in several pathways and played different roles in them. We selected most pathways CRAT participated on our site, such as Beta-oxidation of pristanoyl-CoA,Beta-oxidation of very long chain fatty acids,Fatty Acid Beta Oxidation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Beta-oxidation of pristanoyl-CoA | ACOT8,SCP2B |
| Fatty Acid Beta Oxidation | DECR1,SLC25A20,CPT1B,CPT1A,CHKB,CPT2,ECI1 |
| Metabolism of lipids and lipoproteins | ACOT9.1,CTGF,TMEM195,ECI1,MTP,NFYAL,NFYBB,ARSD,APOA5,CDIPT |
| Beta-oxidation of very long chain fatty acids | ACOT8 |
| Peroxisomal lipid metabolism | SLC27A2A,SLC27A2,SCP2B |
| Peroxisome | PEX11G,ACSL1,NOS2,PEX19,PEX5,PEX11B,PEX10,FAR1,AMACR,PXMP4 |
| Metabolism | ADSS,AK8,PHOSPHO1,ACSF2,DUT,SLC6A7,CYP2K19,TMEM195,DHODH,CETP |
Protein Function
CRAT has several biochemical functions, for example, carnitine O-acetyltransferase activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRAT itself. We selected most functions CRAT had, and list some proteins which have the same functions with CRAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | SRMS,SRI,GRIN2A,C1QTNF2,TENC1,PTK2AA,TAC3,PTK2AB,FGF18B,PLA2G1B |
Interacting Protein
CRAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRAT here. Most of them are supplied by our site. Hope this information will be useful for your research of CRAT.
a8k1f4_human;MLF1;NUDCD3;q96be0_human;PPP5C;AARSD1;CACYBP;q7chm9_yerpe;rhaT7;PEX5
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