CPT2
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Official Full Name
carnitine palmitoyltransferase 2 -
Overview
The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. -
Synonyms
CPT2;carnitine palmitoyltransferase 2;carnitine palmitoyltransferase II , CPT1;carnitine O-palmitoyltransferase 2, mitochondrial;CPTASE;mitochondrial;Carnitine O palmitoyltransferase 2;Carnitine O palmitoyltransferase 2 mitochondrial;Carnitine O-palmitoyltransferase 2;Carnitine palmitoyltransferase II;CPT 1;CPT 2;CPT II;CPT1;CPT2_HUMAN;CPTII;MS722;OTTHUMP00000010493;IIAE4
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Zebrafish
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mamanlian cells
- E.coli
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
- N-His&C-Myc
- His&GST
Involved Pathway
CPT2 involved in several pathways and played different roles in them. We selected most pathways CPT2 participated on our site, such as Fatty Acid Beta Oxidation,Fatty acid degradation,Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid degradation | ADH4,ACSL1A,ACSL4B,ACAT1,ACAA2,CYP4A11,ECI2,ADH1A,ACAT2,ACSL5 |
| Metabolism | ELOVL1A,KCNJ11,CKMT2,NUDT16,CRYM,SULT1ST5,FABP9,NUBP1,IP6K3,KCNS3A |
| Mitochondrial LC-Fatty Acid Beta-Oxidation | EHHADH,SLC25A20,ECI1 |
| Import of palmitoyl-CoA into the mitochondrial matrix | SLC25A20 |
| Fatty acid, triacylglycerol, and ketone body metabolism | AGPAT2,THEM5,ACSF2,APOA5,ACOT11A,SIN3B,MED21,YAP1,ACOT10,MTF1 |
| Metabolism of lipids and lipoproteins | COL4A3BP,ARF3,CYP4T8,MED21,APOA4B.2,DGAT1B,SGMS2,GLTPA,PITPNB,PIK3R6 |
| Fatty acid metabolism | ACSL3,ACSL1B,ELOVL5,ACOX1,ACSBG1,SCD,PTPLAD2,ACAA1,ACADL,ACSBG2 |
| Fatty Acid Beta Oxidation | DECR1,ECI1,CRAT,CHKB,CPT1B,SLC25A20,CPT1A |
Protein Function
CPT2 has several biochemical functions, for example, carnitine O-palmitoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CPT2 itself. We selected most functions CPT2 had, and list some proteins which have the same functions with CPT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carnitine O-palmitoyltransferase activity | CPT1C,CPT1B,CPT1A |
Interacting Protein
CPT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPT2.
ICT1;P
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References
- Lavarias, S; Pasquevich, MY; et al. Partial characterization of a malonyl-CoA-sensitive carnitine O-palmitoyltransferase I from Macrobrachium borellii (Crustacea: Palaemonidae). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 152:364-369(2009).
- Fukumoto, K; Pierro, A; et al. Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1683:1-6(2004).
