CPEB2
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Official Full Name
cytoplasmic polyadenylation element binding protein 2 -
Overview
The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
CPEB2;cytoplasmic polyadenylation element binding protein 2;cytoplasmic polyadenylation element-binding protein 2;CPE binding protein 2;CPE BP2;CPEBP2;hCPEB2;OTTHUMP00000115833;OTTHUMP00000115834;OTTHUMP00000217612;OTTHUMP00000217613;OTTHUMP00000217614;CPE-binding protein 2;CPEB-2;CPE-BP2;hCPEB-2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CPEB2-11517H | Recombinant Human CPEB2 protein, His-tagged | E.coli | Human | His |
Involved Pathway
CPEB2 involved in several pathways and played different roles in them. We selected most pathways CPEB2 participated on our site, such as Dorso-ventral axis formation,Oocyte meiosis,Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPEB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dorso-ventral axis formation | MAP2K1,SPIRE1A,ETV6,GRB2A,CPEB4,NOTCH1A,MAPK3,PPP1R2P9,PIWIL2,SPIRE2 |
| Oocyte meiosis | CALM1B,SMC1A,ANAPC2,CALM3,IGF1,FBXW11B,PPP3R2,MAP2K1,PPP1R2P9,PLK1 |
| Progesterone-mediated oocyte maturation | MAPK1,RPS6KAL,MAD1L1,FZR1A,PIK3R3B,PDE3B,INS,ANAPC5,PRKACG,GNAI2B |
Protein Function
CPEB2 has several biochemical functions, for example, GTPase inhibitor activity,mRNA 3-UTR AU-rich region binding,mRNA 3-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPEB2 itself. We selected most functions CPEB2 had, and list some proteins which have the same functions with CPEB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribosomal large subunit binding | NPM1,MRRF,MALSU1,NMD3,RBM3,EIF6,OLA1 |
| ribosome binding | NAA16,CPEB4,HSPA5,EIF2S1B,EIF5A2,CPEB1,RPSA,SEC61A1,EIF2A,CPEB1B |
| ribosomal small subunit binding | MTIF3,PTCD3,NPM1,ERAL1,DDX3X,NME1,PIM1,DHX29 |
| nucleotide binding | MKNK2B,RDM1,NT5C3B,MYEF2,RHOUA,CAMK1DB,IFT22,DNM2B,KALRN,ADCY2B |
| mRNA 3-UTR binding | PARN,RNF40,RBMS3,TUT1,CARHSP1,CPEB1A,PPP1R2P9,SECISBP2,ELAVL1,IGF2BP1 |
| poly-pyrimidine tract binding | PTBP1,U2AF2 |
| translation factor activity, RNA binding | EIF4G3,EEF2K,EIF1,EIF4H,GTF2H3,CPEB4,EIF4G1,CPEB1A,MTIF3,EIF4E2 |
| GTPase inhibitor activity | CDC42SE1,GPS2,PDE6D,RHOH,IPO5,GPS1,ARL2,UBE4A,TNK2,SLIT2 |
| translation repressor activity, nucleic acid binding | CPEB4,CELF4,CPEB3,PAIP2B,PPP1R2P9,PURA,CELF1,CPEB1A,CPEB1B,CPEB1 |
Interacting Protein
CPEB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPEB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPEB2.
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