COG2
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Official Full Name
component of oligomeric golgi complex 2 -
Overview
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants. -
Synonyms
COG2;component of oligomeric golgi complex 2;LDLC, low density lipoprotein receptor defect C complementing;conserved oligomeric Golgi complex subunit 2;Brefeldin A sensitive peripheral Golgi protein;COG 2;COG complex subunit 2;Conserved oligomeric Golgi complex component 2;LDLC;Low density lipoprotein receptor defect C complementing protein;Transcript ch4822;OTTHUMP00000035875;OTTHUMP00000035876;conserved oligomeric Golgi complex protein 2;brefeldin A-sensitive, peripheral Golgi protein;low density lipoprotein receptor defect C complementing;l
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COG2-12534Z | Recombinant Zebrafish COG2 | Mammalian Cell | Zebrafish | His |
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| COG2-1622H | Recombinant Human COG2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| COG2-3706M | Recombinant Mouse COG2 Protein | Mammalian Cell | Mouse | His |
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| COG2-7385HCL | Recombinant Human COG2 293 Cell Lysate | HEK293 | Human | Non |
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| COG2-1841M | Recombinant Mouse COG2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COG2-1841M-B | Recombinant Mouse COG2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COG2-2080HF | Recombinant Full Length Human COG2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 738 amino acids |
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| Cog2-2235M | Recombinant Mouse Cog2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| COG2-3345H | Recombinant Human COG2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
COG2 involved in several pathways and played different roles in them. We selected most pathways COG2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with COG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
COG2 has several biochemical functions, for example, protein binding,protein complex binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COG2 itself. We selected most functions COG2 had, and list some proteins which have the same functions with COG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein transporter activity | PGAP2,RANBP6,C11orf73,SOSTDC1B,CHMP7,RAMP2,XPO1,KPNA7,TIMM9,KPNA5 |
| protein binding | RHBDD1,ZNF643,EIF2AK3,ATM,KIAA1267,ETV7,EVLA,RND2,C6orf130,DCC |
| protein complex binding | CDKN1B,LCK,RNF40,MYSM1,TXN2,UFD1L,ABI2,DISC1,UGT1A6A,ARRB2 |
Interacting Protein
COG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COG2.
COG4;q7ard3_yerpe;dnaX;q81za2_bacan;emrA
Resources
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References
- Li, XL; Yu, H; et al. Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 41:503-507(2014).
- Herrick-Davis, K; Grinde, E; et al. Oligomer Size of the Serotonin 5-Hydroxytryptamine 2C (5-HT2C) Receptor Revealed by Fluorescence Correlation Spectroscopy with Photon Counting Histogram Analysis EVIDENCE FOR HOMODIMERS WITHOUT MONOMERS OR TETRAMERS. JOURNAL OF BIOLOGICAL CHEMISTRY 287:23604-23614(2012).
