CLTC

  • Official Full Name

    clathrin, heavy chain (Hc)

  • Overview

    Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

  • Synonyms

    CLTC;clathrin, heavy chain (Hc);Hc;CHC;CHC17;CLH-17;CLTCL2;clathrin heavy chain 1;clathrin, heavy polypeptide (Hc);clathrin, heavy polypeptide-like 2;clathrin heavy chain on chromosome 17

Recombinant Proteins

  • Rat
  • Human
  • Chicken
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • His
  • GST
  • Avi&Fc&His
  • GST&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLTC-1471R Recombinant Rat CLTC Protein Mammalian Cells Rat His
CLTC-26707TH Recombinant Human CLTC, GST-tagged Wheat Germ Human GST
CLTC-3605C Recombinant Chicken CLTC Mammalian Cells Chicken His
CLTC-3612M Recombinant Mouse CLTC Protein Mammalian Cells Mouse His
CLTC-1129R Recombinant Rat CLTC Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CLTC-1129R-B Recombinant Rat CLTC Protein Pre-coupled Magnetic Beads HEK293 Rat
CLTC-1773M Recombinant Mouse CLTC Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CLTC-1773M-B Recombinant Mouse CLTC Protein Pre-coupled Magnetic Beads HEK293 Mouse
CLTC-802H Recombinant Human CLTC Protein, His&GST-tagged E.coli Human GST&His Ala2-Pro242

    Involved Pathway

    CLTC involved in several pathways and played different roles in them. We selected most pathways CLTC participated on our site, such as Adaptive Immune System,Arf6 trafficking events,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLTC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Beta-catenin independent WNT signaling AP2A2,AP2S1,AP2M1,GNB5,DVL3,CTNNB2,DVL2,ITPR2,AP2B1,AGO3
    Bacterial invasion of epithelial cells CTNNA3,WASL,CDH1,WASF2,HCLS1,CTNNA1,ITGB1,CDC42,GAB1,DNM1
    Axon guidance DNM1,NTN1B,ACTR2,COL9A1B,ARPC4,NCK1,EPHA10,SRGAP1,DUSP2,CNKSR1
    Developmental Biology RGMB,CEBPB,COL4A4,KALRN,MED22,MED20,AP2A2,PITPNA,ACTR2B,PLXNC1
    EPH-Ephrin signaling MYL12A,SHB,EFNA4,EFNB2,EPHB4B,SDCBP,EFNA1A,EPHB4A,AP2B1,EPHA2
    Arf6 trafficking events EXOC5,CTNND1,SCAMP2,ADRB2,PTBP3,EXOC6,CPE,DNM2,EXOC3,JUP
    Adaptive Immune System LAIR1,HCST,LRRC41,TRIM41,KIF26A,KLRB1B,RAP1GAP2B,SIGLEC12,FBXO27,CXADR
    Clathrin derived vesicle budding BLOC1S4,FTH1A,NAPAA,NECAP1,AP1S1,AP4B1,SNX9A,DNM2,CLTB,SNAPIN

    Protein Function

    CLTC has several biochemical functions, for example, clathrin light chain binding,double-stranded RNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLTC itself. We selected most functions CLTC had, and list some proteins which have the same functions with CLTC. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding EIF2S1A,MRM1,RBM4,HOXB6,WDR43,PEF1,MATR3,CD3EAP,SRSF2,SRSF3
    protein binding KRTAP9-2,PEX2,FAM58A,MTUS2,EDDM3B,PLLP,EN1,THOC4,GSE1,ZNRF1
    structural molecule activity IFLTD1,SNTG2,KRT28,KRT33B,COL15A1B,JUPA,LAMA3,DESMB,INAB,KRT81
    protein kinase binding PARK2,PRKAG1,NBEA,CD36,TRAF4,PPP1R12C,SHC3,PARN,YWHAZ,FAM83B
    double-stranded RNA binding EIF2C3,ELAVL1,APTX,TLR8,STRBP,IFIH1,MYH4,DDX21,PRKRIP1,ZNF346
    clathrin light chain binding NSG2,HMP19,CALY,NSG1

    Interacting Protein

    CLTC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLTC here. Most of them are supplied by our site. Hope this information will be useful for your research of CLTC.

    OCRL;TNK2;IKBKB;IKBKE;HIP1;C10orf88;TOM1L1

    CLTC Related Signal Pathway

    Resources

    Research Area

    Synaptic Proteins
    Clathrin-mediated Endocytosis
    p53 Pathway

    References

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