CLSPN

  • Official Full Name

    claspin

  • Overview

    The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

  • Synonyms

    CLSPN;claspin;hClaspin;claspin homolog
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLSPN-3607M Recombinant Mouse CLSPN Protein Mammalian Cells Mouse His
CLSPN-4247C Recombinant Chicken CLSPN Mammalian Cells Chicken His
CLSPN-1770M Recombinant Mouse CLSPN Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CLSPN-1770M-B Recombinant Mouse CLSPN Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    CLSPN involved in several pathways and played different roles in them. We selected most pathways CLSPN participated on our site, such as Activation of ATR in response to replication stress,Apoptosis,Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLSPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Double-Strand Break Repair DNA2,TIPIN,EYA2,EME2,RAD9B,BAZ1B,PARP1,EME1,HTATIP,RAD50
    Cell cycle HJURP,RCC2,MIS12,PANE1,SMAD3B,TP53,MCM4,DKC1,CCNB1,MYCA
    Apoptotic cleavage of cellular proteins LMNB1,DBNLA,SATB1,PLECA,CASP6L1,CASP6L2,DSP,PKP1,CTNNB1,CTNNB2
    DNA Repair PARP2,GPS1,TP53BP1,YY1A,YY1,EME2,MAD2L2,HUS1,CHEK2,UIMC1
    Apoptosis DSG1,HMGB2,AKT3A,BIRC2,BIRC5A,BCL2,CFLAR,RIPK1L,CASP7,TNFRSF10C
    Cell Cycle Checkpoints TP53BP1,RAD9A,RAD17,RAD9B,BABAM1,THRSP,DBF4,UIMC1,RAD50,FAM175A
    Apoptotic execution phase GAS2,SATB1,SPNA2,BCAP31,STK24,H1F0,HIST1H1E,BMX,DNM1L,OCLN
    Activation of ATR in response to replication stress RAD9B,RAD1,CDK2,HUS1,CHEK1,MCM10,RAD9A,DBF4,RAD9,MCM8

    Protein Function

    CLSPN has several biochemical functions, for example, DNA binding,DNA secondary structure binding,anaphase-promoting complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLSPN itself. We selected most functions CLSPN had, and list some proteins which have the same functions with CLSPN. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding PMS1,H2AFV,RAD54L,HOXC9,IRF7,SIM1A,TLR8,THAP4,TIGD5,EMX1
    anaphase-promoting complex binding PTEN,PLK1

    Interacting Protein

    CLSPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLSPN here. Most of them are supplied by our site. Hope this information will be useful for your research of CLSPN.

    MCM3;INPP5B;MCM4;MCM5;MCM7;MCM2;MCM6;PNKD;RAPGEF6;RNF170;TMEM246;GINS4;MMTAG2;TIPIN;KIF26A;TIMELESS

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