CLPS
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Official Full Name
colipase, pancreatic -
Overview
The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. -
Synonyms
CLPS;colipase, pancreatic;colipase;Colipase pancreatic;Pancreatic colipase preproprotein;OTTHUMP00000016271
Recombinant Proteins
- Human
- Rat
- Streptomyces coelicolor A3(2)
- Chicken
- E.coli
- Mouse
- E.coli
- Insect Cells
- HEK293
- E.Coli/Yeast
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
CLPS involved in several pathways and played different roles in them. We selected most pathways CLPS participated on our site, such as Digestion of dietary lipid,Fat digestion and absorption,Lipid digestion, mobilization, and transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLPS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lipid digestion, mobilization, and transport | APOC2,FABP11B,LPA,APOA1B,LMF1,APOA5,Alb,FABP11A,APOA4B.2,FABP12 |
| Visual phototransduction | METAP2,RLN1,GUCA1E,RPE65B,APOA4B.1,RDH10,IRBP,RDH12,APOA4A,METAP2B |
| Signal Transduction | CSNK1G2,FAM13B,DZIP1,PMEPA1,STRA6,FSTL3,RSPO2,CD97,RIT1,GPR161 |
| Metabolism of lipids and lipoproteins | SUMF2,ALOX5AP,FA2H,PTGR1,SLCO1B1,PEMT,APOA4B.2,CSNK1G2,PLD6,CYP27B1 |
| Digestion of dietary lipid | LMF2,LMF1 |
| Metabolism | SLC25A32B,GNG13B,PLD6,ACOT11,DCT,CPOX,CTGF,CYGB,IP6K3,MED29 |
| Fat digestion and absorption | AGPAT2,ABCG8,SCARB1,PLA2G12B,SLC27A4,APOA4,DGAT1,PLA2G2E,Cel,PNLIPRP2 |
| Retinoid metabolism and transport | AKR1C6,APOM,APOA4B.1,AKR1C4,RBP4,BCO2,RBP2A,BCO2L,RBP1,LRP12 |
Protein Function
CLPS has several biochemical functions, for example, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLPS itself. We selected most functions CLPS had, and list some proteins which have the same functions with CLPS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | SAE1,PRKCD,DAOA,DBNL,UBA2,CLPSL1,GLC8,MMP17,PPP1R12B,TRIM23 |
Interacting Protein
CLPS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLPS here. Most of them are supplied by our site. Hope this information will be useful for your research of CLPS.
Resources
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References
- Itoh-Nakadai, A; Hikota, R; et al. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. NATURE IMMUNOLOGY 15:1171-1180(2014).
- Lange, M; Fiedler, M; et al. Hepatitis C Virus Hypervariable Region 1 Variants Presented on Hepatitis B Virus Capsid-Like Particles Induce Cross-Neutralizing Antibodies. PLOS ONE 9:-(2014).
