CLK4
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Official Full Name
CDC-like kinase 4 -
Overview
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. -
Synonyms
CLK4;CDC-like kinase 4;dual specificity protein kinase CLK4;OTTMUSP00000005756;OTTMUSP00000005757;OTTMUSP00000041113;AI987988;C85119;CDC like kinase 4;DKFZp686A20267;Protein serine threonine kinase Clk4;RP23-9N7.1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Insect Cell
- Insect (sf21)
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
CLK4 involved in several pathways and played different roles in them. We selected most pathways CLK4 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | LOC100862398,HNRNPL,ZFP740,PTBP1,BICC1,HNRPL,SUGP2,CELF4,D19BWG1357E,CELF2 |
Protein Function
CLK4 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLK4 itself. We selected most functions CLK4 had, and list some proteins which have the same functions with CLK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine/tyrosine kinase activity | DYRK1AA,AURKB,PRKACA,CLK3,DSTYK,AURKC,PRKAA2,SGK1,PRKCG,TESK2 |
| protein binding | MIEF1,FAM124B,SYNJ2,ZFP36,PIH1D2,REST,C4BPA,MPDU1,ACACA,PCK2 |
| protein tyrosine kinase activity | INSR,FGFR2,MUSK,PTK2AA,SYK,ABL2,PDGFRB,CAMKK2,FGFR4,MATK |
| protein serine/threonine kinase activity | TLK1B,MAPK14B,MAP3K4,MLKL,ADCK4,ACVR2A,STK31,TAF1L,EIF2AK4,DMPK |
| ATP binding | Acsm2a,HNRNPU,MAP3K14,RUNX2,TTLL9,HIPK1,NUBP1,ATP1A1A.4,CHD1,ASNS |
Interacting Protein
CLK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLK4.
KPNA1;KRTAP10-7;KRTAP10-8;KRTAP10-9;SRPK1;UBL5;RNF181;RGMA;AHCYL2
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