CLIP3
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Official Full Name
CAP-GLY domain containing linker protein 3 -
Overview
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
CLIP3;CAP-GLY domain containing linker protein 3;CAP-Gly domain-containing linker protein 3;CLIP 170 related;CLIPR 59;restin like 1;RSNL1;CAP GLY domain containing linker protein 3;CLIP 170 related 59 kDa protein;CLIP-170-related 59 kDa protein;CLIP3_HUMAN;CLIPR-59;CLIPR59;Cytoplasmic linker protein 170 related 59 kDa protein;Cytoplasmic linker protein 170-related 59 kDa protein;restin-like 1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- GST
- His
- Non
- His&Fc&Avi
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLIP3-1489H | Recombinant Human CLIP3 Protein, GST-tagged | Wheat Germ | Human | GST | 447-547 a.a. |
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| CLIP3-3584M | Recombinant Mouse CLIP3 Protein | Mammalian Cell | Mouse | His |
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| CLIP3-911R | Recombinant Rhesus monkey CLIP3 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CLIP3-7443HCL | Recombinant Human CLIP3 293 Cell Lysate | HEK293 | Human | Non |
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| CLIP3-1758M | Recombinant Mouse CLIP3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CLIP3-1758M-B | Recombinant Mouse CLIP3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CLIP3-3258H | Recombinant Human CLIP3 Protein, GST/His-tagged | E.coli | Human | His&GST |
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| CLIP3-736R | Recombinant Rhesus Macaque CLIP3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CLIP3-736R-B | Recombinant Rhesus Macaque CLIP3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CLIP3 involved in several pathways and played different roles in them. We selected most pathways CLIP3 participated on our site, such as Death Receptor Signalling,Regulation of TNFR1 signaling,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF signaling | FAM105B,OTUD7B,SHARPIN,USP2,TAX1BP1B,RBCK1,SHRPRBCK1R,RNF31,OTULINB,TAX1BP1 |
| Signal Transduction | PTH,HCRT,GPR31B,RBP2A,CRABP2B,DTX2,BBS13,WIF1,OXTRL,NPSR1 |
| Regulation of TNFR1 signaling | USP4,TAX1BP1B,OTUD7B,RNF31,TAX1BP1,OTULIN,SHRPRBCK1R,FAM105B,RBCK1,SHARPIN |
| Death Receptor Signalling | FAM105B,SHRPRBCK1R,USP4,TAB1,CYLD,OTULIN,RBCK1,SHARPIN,OTUD7B,TAX1BP1 |
Protein Function
CLIP3 has several biochemical functions, for example, ganglioside binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIP3 itself. We selected most functions CLIP3 had, and list some proteins which have the same functions with CLIP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | FAM154A,CEP57L1,KIF5AA,DPYSL2B,KIF15,PRNP,MAP1LC3B,MTAP1A,PRC1B,MTAP6 |
Interacting Protein
CLIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIP3.
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References
- Ciecholewski, M; et al. Ischemic heart disease detection using selected machine learning methods. INTERNATIONAL JOURNAL OF COMPUTER MATHEMATICS 90:1734-1759(2013).
- Couesnon, A; Offner, N; et al. CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. DEVELOPMENT 140:1583-1593(2013).
