CLINT1
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Official Full Name
clathrin interactor 1 -
Overview
This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. -
Synonyms
CLINT1;clathrin interactor 1;CLINT;ENTH;EPNR;KIAA0171;epsinR;epsin 4;enthoprotin;epsin-related protein;clathrin interacting protein localized in the trans-Golgi region;EPN4;FLJ46753
Recombinant Proteins
- Human
- Chicken
- Wheat Germ
- Mammalian Cells
- HEK293
- Yeast
- In Vitro Cell Free System
- E.coli
- GST
- His
- Non
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLINT1-1485H | Recombinant Human CLINT1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLINT1-2324C | Recombinant Chicken CLINT1 | Mammalian Cells | Chicken | His |
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| CLINT1-7444HCL | Recombinant Human CLINT1 293 Cell Lysate | HEK293 | Human | Non |
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| CLINT1-2021H | Recombinant Human CLINT1 Protein (1-625 aa), His-tagged | Yeast | Human | His | 1-625 aa |
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| CLINT1-2187HF | Recombinant Full Length Human CLINT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 625 amino acids |
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| CLINT1-2701H | Recombinant Human CLINT1 protein, His-tagged | E.coli | Human | His | 1-625aa |
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| CLINT1-2702H | Recombinant Human CLINT1 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-625aa |
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| CLINT1-3257H | Recombinant Human CLINT1 Protein, His-tagged | E.coli | Human | His |
|
Involved Pathway
CLINT1 involved in several pathways and played different roles in them. We selected most pathways CLINT1 participated on our site, such as Clathrin derived vesicle budding,Golgi Associated Vesicle Biogenesis,Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLINT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| trans-Golgi Network Vesicle Budding | SNX9,TPD52L1,DNASE2,TCEAL4,PUM1,FTH1B,FTH1A,AP4B1,PLDN,SH3D19 |
| Golgi Associated Vesicle Biogenesis | CNO,HIP1RB,PICALMB,SH3D19,PICALM,AP1S3A,BLOC1S1,AP4B1,TPD52L1,FTH1A |
| Clathrin derived vesicle budding | FTH1A,PPIAL4A,PICALM,TCEAL4,TFR1B,SNX9A,NECAP1,AP1B1,SNAPIN,FTH1B |
| Vesicle-mediated transport | HSPH1,TRAPPC9,GJA4,ARCN1,SNAPIN,HYOU1,FTH1A,BLOC1S1,TBC1D8B,SNX9 |
| Membrane Trafficking | GJA8,DNASE2,COPE,SNX9,ARCN1A,NAPAB,GAK,FTH1A,NAPB,HIP1R |
Protein Function
CLINT1 has several biochemical functions, for example, clathrin binding,lipid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLINT1 itself. We selected most functions CLINT1 had, and list some proteins which have the same functions with CLINT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid binding | MAL,AMER2,CRABP1B,ACOT12,PLUNC,SH3GL1,HSP12,PITPNC1,Alb,BPIFB6 |
| protein binding | BCAP31,MMP2,ERO1LB,STUB1,USP9X,RNPS1,EXOC8,TBX2A,SPANXA1,NOC2L |
| clathrin binding | SYTL4,SYT6,SYT5A,HIP1,LDLRAP1,HIP1R,SYT1A,PICALMA,SYT1B,SYTL1 |
Interacting Protein
CLINT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLINT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLINT1.
Ap1g1;MAP1LC3B;GABARAPL1;MAP1LC3A;GABARAP;GABARAPL2;MAP1LC3C
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References
- Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
