CLEC1B
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Official Full Name
C-type lectin domain family 1, member b -
Overview
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM;602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and;either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in;myeloid cells and NK cells (Colonna et al., 2000 (PubMed 10671229)). -
Synonyms
CLEC1B;C-type lectin domain family 1, member b;C-type lectin domain family 1 member B;1810061I13Rik;C type lectin domain family 1 member B;C type lectin like receptor 2;C-type lectin-like receptor 2;C-type lectin-like receptor-2;CLC1B_HUMAN;CLEC 2;CLEC 2B;CLEC-2;CLEC2;CLEC2B;PRO1384;QDED721;OTTMUSP00000033486;OTTMUSP00000033487
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- HEK293
- Wheat Germ
- Insect Cell
- Mammalian Cell
- Human Cell
- Rabbit
- In Vitro Cell Free System
- GST
- His
- Fc
- Non
- His&Fc&Avi
Involved Pathway
CLEC1B involved in several pathways and played different roles in them. We selected most pathways CLEC1B participated on our site, such as GPVI-mediated activation cascade,Hemostasis,Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | MFN1,DOCK7,DOCK11,CD9A,F9A,F11R.2,GATA2,AMICA1,WDR1,IRF2 |
| Platelet activation, signaling and aggregation | SPARC,WDR1,SRGN,BRPF3,CD9B,MMRN1,CD9A,GAS6,TRPC6A,PLEK |
| GPVI-mediated activation cascade | PDPN,RHOB,PIK3R6,LCP2A,RHOGA,FCER1GL,G6b,C6orf25 |
Protein Function
CLEC1B has several biochemical functions, for example, carbohydrate binding,protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC1B itself. We selected most functions CLEC1B had, and list some proteins which have the same functions with CLEC1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PDHB,TRADD,KAT8,PARVB,RUFY1,FES,KIT,SNRPG,RNF13,UBA5 |
| carbohydrate binding | FCN3,CLEC19A,CNTN1,LGALS3L,WBSCR17,ILLR4,PKD1L3,MAN2C1,CLEC6A,FCER2 |
| transmembrane signaling receptor activity | SLAMF1,ANTXR1,GHRHRL,EDAR,ENG,OR12D3,NRXN2,GPR126,Cd79a,IL27RA |
Interacting Protein
CLEC1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC1B here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC1B.
NINL
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesC-type Lectin Receptors
Dendritic Cell Activation
Dendritic Cell Pathogen Recognition/Uptake
C-type Lectin Family
Related Services
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References
- Cui, J; Chen, YJ; et al. Mechanisms and pathways of innate immune activation and regulation in health and cancer. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3270-3285(2014).
- Noack, S; Seiffart, V; et al. Periostin Secreted by Mesenchymal Stem Cells Supports Tendon Formation in an Ectopic Mouse Model. STEM CELLS AND DEVELOPMENT 23:1844-1857(2014).
