CLDN16
- Product List
- Overview
- Review / Q&A
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Official Full Name
claudin 16 -
Overview
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. -
Synonyms
CLDN16;claudin 16;claudin-16;HOMG3;hypomagnesemia 3;with hypercalciuria and nephrocalcinosis;paracellin 1;PCLN1;CLD16_HUMAN;CLDN 16;Paracellin-1;PCLN-1;hypomagnesemia 3, with hypercalciuria and nephrocalcinosis
Recombinant Proteins
- Human
- Rat
- Mus musculus
- Bovine
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- Protein Conjugation
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLDN16-11288H | Recombinant Human CLDN16, GST-tagged | E.coli | Human | GST | 1-150a.a. | |
| CLDN16-1433H | Recombinant Human CLDN16 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLDN16-1433R | Recombinant Rat CLDN16 Protein | Mammalian Cells | Rat | His |
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| CLDN16-1091R | Recombinant Rat CLDN16 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| CLDN16-2045HF | Recombinant Full Length Human CLDN16 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 305 amino acids |
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| Cldn16-2788R | Recombinant Rat Cldn16 Protein, His-tagged, OVA Conjugated | Protein Conjugation | Rat | His | Trp137-Gly169 |
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| RFL28330MF | Recombinant Full Length Mouse Claudin-16(Cldn16) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length (1-235) |
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| RFL7201BF | Recombinant Full Length Bovine Claudin-16(Cldn16) Protein, His-Tagged | E.coli | Bovine | His | Full L. Full Length (1-254) |
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| RFL850RF | Recombinant Full Length Rat Claudin-16(Cldn16) Protein, His-Tagged | E.coli | Rat | His | Full L. Full Length (1-235) |
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Involved Pathway
CLDN16 involved in several pathways and played different roles in them. We selected most pathways CLDN16 participated on our site, such as Cell adhesion molecules (CAMs),Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell-cell junction organization | F11R.2,PVRL2L,CDH18,CDH6,CDH7,JUP,CDH4,CDH9,CDH10A,JUPA |
| Tight junction interactions | CLDN4,CLDN3,INADL,CLDN20,CLDN23,CLDN7 |
| Hepatitis C | IL-8,IFIT1,MAPK12,PPP2R2B,PIK3CA,CLDN22,SCARB1,TP53,Ifna11,OAS3 |
| Tight junction | GNAI1,MYH6,HRAS,CLDN9,CLDNA,ASH1L,PRKCH,MYHZ1.1,CLDN8,MYH4 |
| Cell adhesion molecules (CAMs) | CADM1A,VTCN1,JAM2A,PVRL3B,HLA-E,HLA-DPB1,LRRC4,HLA-A,CLDNG,CD2 |
| Leukocyte transendothelial migration | ACTN2,EZR,PTK2B,CLDN8,PIK3R2,NCF1,CLDN9,MAPK13,MYL12B,ICAM1 |
| Cell junction organization | CDH11,LIMS1,CLDN20,CDH18A,CDH8,CDH6,CDH5,CDH9,JUP,ANG |
| Cell-Cell communication | CADM2B,ANG,CDH2,JUP,CADM2,DSCAMA,DCC,KIRREL2,CLDN4,CTNND1 |
Protein Function
CLDN16 has several biochemical functions, for example, identical protein binding,magnesium ion transmembrane transporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN16 itself. We selected most functions CLDN16 had, and list some proteins which have the same functions with CLDN16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| magnesium ion transmembrane transporter activity | NIPAL4,CNNM4,ZDHHC13,NIPAL2,TUSC3,MRS2,MMGT2,NIPAL3,NIPA2,MMGT1 |
| protein binding | CEP290,CAMK2G,ARHGDIG,CRMP1,CDKN2B,CXCL11,PRH1,RBMY1B,MATN3,CLK1 |
| structural molecule activity | CRYBB2,KRT80,Sprr2i,PRR9,IFFO2,EPB41L2,KRT72-PS,CLDN5A,KRT26,KRT76 |
| identical protein binding | BIN1,SQSTM1,ACY3,RAD51,SCHIP1,VWF,DAAM1,PSMD4,CHMP4B,TRIM21 |
Interacting Protein
CLDN16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN16 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN16.
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References
- Agaimy, A; Buslei, R; et al. Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel. HISTOPATHOLOGY 65:60-70(2014).
- Micke, P; Mattsson, JSM; et al. Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer. INTERNATIONAL JOURNAL OF CANCER 135:2206-2214(2014).
