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CLDN12

  • Official Full Name

    Claudin 12

  • Overview

    This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.

  • Synonyms

    Cldn12;claudin-12;OTTHUMP00000024518;OTTHUMP00000067944;OTTHUMP00000082755;OTTHUMP00000212898

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Zebrafish
  • Pongo Abelii
  • Bovine
  • Mus musculus
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • E.coli expression system
  • GST
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLDN12-1429H Recombinant Human CLDN12 Protein, GST-tagged Wheat Germ Human GST
CLDN12-3523M Recombinant Mouse CLDN12 Protein Mammalian Cell Mouse His
CLDN12-892R Recombinant Rhesus monkey CLDN12 Protein, His-tagged Mammalian Cell Rhesus macaque His
CLDN12-9287Z Recombinant Zebrafish CLDN12 Mammalian Cell Zebrafish His
CLDN12-1727M Recombinant Mouse CLDN12 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CLDN12-1727M-B Recombinant Mouse CLDN12 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CLDN12-2040HF Recombinant Full Length Human CLDN12 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 244 amino acids
CLDN12-718R Recombinant Rhesus Macaque CLDN12 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CLDN12-718R-B Recombinant Rhesus Macaque CLDN12 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RFL25050PF Recombinant Full Length Pongo Abelii Claudin-12(Cldn12) Protein, His-Tagged E.coli expression system Pongo Abelii His Full L. Full Length (1-244)
RFL30947BF Recombinant Full Length Bovine Claudin-12(Cldn12) Protein, His-Tagged E.coli expression system Bovine His Full L. Full Length (1-244)
RFL33695HF Recombinant Full Length Human Claudin-12(Cldn12) Protein, His-Tagged E.coli expression system Human His Full L. Full Length (1-244)
RFL8824MF Recombinant Full Length Mouse Claudin-12(Cldn12) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length (1-244)

    Involved Pathway

    CLDN12 involved in several pathways and played different roles in them. We selected most pathways CLDN12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLDN12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    CLDN12 has several biochemical functions, for example, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLDN12 itself. We selected most functions CLDN12 had, and list some proteins which have the same functions with CLDN12. You can find most of the proteins on our site.

    Function Related Protein
    structural molecule activity MAP7,KRT39,NCR3LG1,KRT1-C5,CLDNF,CLDN5A,LCE1F,KRT8,KRT34,CLDN9

    Interacting Protein

    CLDN12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLDN12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLDN12.

    Resources

    Research Area

    Tight Junction Proteins in Endothelial Cells
    Epithelial Cell Markers and Intracellular Molecules
    Glial Lineage Markers
    Claudins
    Tight Junctions

    References

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