CKAP5
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Official Full Name
cytoskeleton associated protein 5 -
Overview
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
CKAP5;cytoskeleton associated protein 5;cytoskeleton-associated protein 5;ch TOG;KIAA0097;TOG;TOGp;colonic and hepatic tumor overexpressed gene protein;colonic and hepatic tumor over-expressed gene protein;MSPS;CHTOG;ch-TOG;FLJ35359
Recombinant Proteins
- Mouse
- Zebrafish
- Chicken
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CKAP5-3493M | Recombinant Mouse CKAP5 Protein | Mammalian Cell | Mouse | His |
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| CKAP5-3565Z | Recombinant Zebrafish CKAP5 | Mammalian Cell | Zebrafish | His |
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| CKAP5-4439C | Recombinant Chicken CKAP5 | Mammalian Cell | Chicken | His |
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| CKAP5-1706M | Recombinant Mouse CKAP5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CKAP5-1706M-B | Recombinant Mouse CKAP5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CKAP5-301363H | Recombinant Human CKAP5 protein, GST-tagged | E.coli | Human | GST | Met1-Val349 |
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| CKAP5-791H | Recombinant Human CKAP5 Protein, His-tagged | E.coli | Human | His | Met1-Ala198 |
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Involved Pathway
CKAP5 involved in several pathways and played different roles in them. We selected most pathways CKAP5 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CKAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | B9D2,CDKN1B,HIST3H2BB,NDEL1A,ENSAA,CDK6,MAPRE1A,CETN2,E2F4,STIL |
| Cell cycle | TSGA14,MIS18BP1,FZR1A,ORC3,SGOL1,LIN9,NIPBLB,SMAD3A,AHCTF1,RAD21B |
| Assembly of the primary cilium | HDAC6,IFT22,IFT46,DCTN2,TNPO1,DYNLL2,BBS10,TTC30B,DCTN1,BBS9 |
| G2/M Transition | PCM1,CCP110,CEP135,MAPRE1,CEP70,NDE1,FOXM1,CLASP1,CEP63,BORA |
| Anchoring of the basal body to the plasma membrane | DCTN1,CC2D2A,NINL,CEP290,CSNK1E,CLASP1A,TMEM216,HAUS2,ACTR1A,NPHP1 |
| Loss of proteins required for interphase microtubule organizationfrom the centrosome | CP110,CEP164,CEP290,SSNA1,HAUS2,NDE1,CEP78,CEP72,CEP76,CCP110 |
| Centrosome maturation | MAPRE1A,OFD1,CLASP1A,TUBGCP4,ODF2,CENPJ,TUBG2,TUBGCP5,DYNC1H1,DCTN1 |
| Loss of Nlp from mitotic centrosomes | CEP57,CEP164,CEP70,SSNA1,CLASP1A,CEP290,NDE1,SDCCAG8,PLK4,ODF2B |
Protein Function
CKAP5 has several biochemical functions, for example, microtubule binding,ribonucleoprotein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CKAP5 itself. We selected most functions CKAP5 had, and list some proteins which have the same functions with CKAP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | SERPINB1A,KIF5B,CETN1,SBDS,KIF5A,KIF7,MTAP1B,FMR1,ZFP207,MTAP4 |
| ribonucleoprotein complex binding | SRP54,CD2BP2,RNASEL,PES,RNF135,SECISBP2,PES1,PRPF31,YBX2,BOP1 |
Interacting Protein
CKAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CKAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CKAP5.
TACC3;b2rcx0_human;q8iw51;APC;CKAP5;DYNC1H1;CCHCR1;RBPMS;ACADM;SLAIN2;TACC2;ERLIN1;HSPD1;PC;KRT5;ATP5A1;LONP1;ETFB;MTOR
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References
- Morielli, T; O'Flaherty, C; et al. Oxidative stress impairs function and increases redox protein modifications in human spermatozoa. REPRODUCTION 149:113-123(2015).
- de Leon, CTG; Martin, RDD; et al. Proteomic characterization of the subpellicular cytoskeleton of Toxoplasma gondii tachyzoites. JOURNAL OF PROTEOMICS 111:86-99(2014).
