CHRNB3
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Official Full Name
CHRNB3 cholinergic receptor, nicotinic, beta 3 -
Overview
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[ -
Synonyms
CHRNB3;cholinergic receptor, nicotinic, beta 3;neuronal acetylcholine receptor subunit beta-3;OTTHUMP00000229136;cholinergic receptor, nicotinic, beta polypeptide 3;acetylcholine receptor, neuronal nicotinic, beta-3 subunit
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- GST
- His
- Fc
- His&T7
- His&Fc&Avi
Involved Pathway
CHRNB3 involved in several pathways and played different roles in them. We selected most pathways CHRNB3 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | CHRM5A,GABRD,PTGER4A,GLRA2,VIPR2,P2RX3B,PTH1RB,TACR1,TSHR,MLNR |
Protein Function
CHRNB3 has several biochemical functions, for example, acetylcholine binding,acetylcholine-activated cation-selective channel activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB3 itself. We selected most functions CHRNB3 had, and list some proteins which have the same functions with CHRNB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular ligand-gated ion channel activity | SIX2A,CHRNB1L,Chrng,GABRP,GLRBB,CHRNA4B,CHRNA10A,GABRR3A,GLRA4A,GLRA4B |
| acetylcholine-activated cation-selective channel activity | CHRNB1L,CHRNA4B,CHRNE,CHRNA2,CHRNA1,CHRNA5,CHRNA3,CHRNA6,CHRNA7,CHRNB2 |
| ion channel activity | CACNA1BA,KCNC1B,Chrng,TRPM1B,KCNH5A,KCNV2B,TRPM1A,FXYD7,KCNC2,KCNK3 |
| drug binding | PPP3CA,PDE2A,NAMPT,TYMS,TLR8,HTR2A,ADH1,PDE10A,CHRM2,UGT1A7 |
| acetylcholine binding | ACHE,CHRM3,CHRNA3,CHRNB2,CHRNA4,CHRNB1,CHRFAM7A,CHRNA7 |
Interacting Protein
CHRNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB3.
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References
- Tseng, TS; Park, JY; et al. Role of Nicotine Dependence on the Relationship between Variants in the Nicotinic Receptor Genes and Risk of Lung Adenocarcinoma. PLOS ONE 9:-(2014).
- Bar-Shira, A; Gana-Weisz, M; et al. CHRNB3 c.-57A > G functional promoter change affects Parkinson's disease and smoking. NEUROBIOLOGY OF AGING 35:-(2014).
