CHRNB1
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Official Full Name
cholinergic receptor, nicotinic, beta 1 (muscle) -
Overview
The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. -
Synonyms
CHRNB1;cholinergic receptor, nicotinic, beta 1 (muscle);acetylcholine receptor subunit beta;Acetylcholine receptor protein beta chain precursor;ACHB_HUMAN;ACHRB;Cholinergic receptor nicotinic beta polypeptide 1 (muscle);Chrnb 1;CHRNB;CMS1D;CMS2A;Nicotinic acetylcholine receptor beta subunit precursor;SCCMS;cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHRNB1-1285H | Recombinant Human CHRNB1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CHRNB1-1396R | Recombinant Rat CHRNB1 Protein | Mammalian Cell | Rat | His |
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| Chrnb1-3054R | Recombinant Rat Chrnb1, His-tagged | E.Coli or Yeast | Rat | His | 501 |
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| CHRNB1-3055C | Recombinant Chicken CHRNB1, His-tagged | E.Coli or Yeast | Chicken | His | 118 |
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| CHRNB1-3438M | Recombinant Mouse CHRNB1 Protein | Mammalian Cell | Mouse | His |
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| CHRNB1-8108Z | Recombinant Zebrafish CHRNB1 | Mammalian Cell | Zebrafish | His |
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| CHRNB1-187HCL | Recombinant Human CHRNB1 lysate | HEK293 | Human | Non |
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| CHRNB1-1054R | Recombinant Rat CHRNB1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CHRNB1-1054R-B | Recombinant Rat CHRNB1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CHRNB1-1668M | Recombinant Mouse CHRNB1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CHRNB1-1668M-B | Recombinant Mouse CHRNB1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
CHRNB1 involved in several pathways and played different roles in them. We selected most pathways CHRNB1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | TAAR10C,GRIN1A,MC5RB,GZMA,GABBR1,OPRD1B,TAAR13B,GABRA2,NPY8BR,FPR3 |
Protein Function
CHRNB1 has several biochemical functions, for example, contributes_to acetylcholine binding,acetylcholine binding,contributes_to acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB1 itself. We selected most functions CHRNB1 had, and list some proteins which have the same functions with CHRNB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to acetylcholine receptor activity | CHRNB3A,CHRNB1L,CHRNA10,CHRNA10A,CHRFAM7A,CHRND,CHRNB3B,CHRNA9,CHRNA2A,CHRNA1 |
| contributes_to acetylcholine binding | CHRNB1L,CHRNA1,CHRNA6,CHRNB4,CHRND,CHRNA10A,CHRNA5,CHRNA10,CHRNE,CHRNB3A |
| acetylcholine binding | ACHE,CHRNB2,CHRM3,CHRNB3,CHRNA4,CHRNA7,CHRFAM7A,CHRNA3 |
| contributes_to acetylcholine-activated cation-selective channel activity | ZACN,CHRNB3B,CHRNA10,CHRNA4B,CHRFAM7A,CHRNB3A,CHRNA9,CHRNA1,CHRNA10A,CHRNA2A |
| channel activity | APNL,BAXB,GJA8,BCL2,P2RX6,MAL,BAX,STEAP1,PANX1A,BAXA |
| ligand-gated ion channel activity | CLCA2,CHRNA5,GABRB1,CHRNB4,CNGA3,CHRNA3,ANXA6,P2RX2,TRPA1A,ZACN |
Interacting Protein
CHRNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB1.
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References
- Lindstrom, J; Luo, J; et al. Myasthenia gravis and the tops and bottoms of AChRs - Antigenic structure of the MIR and specific immunosuppression of EAMG using AChR cytoplasmic domains. MYASTHENIA GRAVIS AND RELATED DISORDERS: 11TH INTERNATIONAL CONFERENCE 1132:29-41(2008).
- Hayashi, K; et al. Biochemical studies on functional proteins in the brain nervous system. Neurobiochemical studies on nerve growth factor. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 116:286-308(1996).
- SINE, SM; CLAUDIO, T; et al. STABLE EXPRESSION OF THE MOUSE NICOTINIC ACETYLCHOLINE-RECEPTOR IN MOUSE FIBROBLASTS - COMPARISON OF RECEPTORS IN NATIVE AND TRANSFECTED CELLS. JOURNAL OF BIOLOGICAL CHEMISTRY 266:13679-13689(1991).
