CHRNA5
-
Official Full Name
cholinergic receptor, nicotinic, alpha 5 -
Overview
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2). -
Synonyms
CHRNA5;LNCR2;cholinergic receptor, nicotinic, alpha 5;neuronal acetylcholine receptor subunit alpha-5;OTTHUMP00000185019;neuronal nicotinic acetylcholine receptor, alpha5 subunit;Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Pan troglodytes
- Rat
- Bovine
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
CHRNA5 involved in several pathways and played different roles in them. We selected most pathways CHRNA5 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Highly calcium permeable nicotinic acetylcholine receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acetylcholine Binding And Downstream Events | CHRND,CHRNA1,CHRNE,CHRNA3,CHRNA2,CHRNB2,CHRNB4,CHRNA4,CHRNA7 |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | CHRNA1,CHRNB2,CHRNA4,CHRNA2,CHRNB4,CHRNA7,CHRNA3 |
| Highly calcium permeable nicotinic acetylcholine receptors | CHRNA4,CHRNB2,CHRNA1,CHRNA3,CHRNB4,CHRNA2 |
| Neuronal System | KCNQ2,KCNK2B,KCNS3A,PICK1,KCNN2,KCNA5,KCNB1,CHRNB4,SYN1,KCNJ11 |
| Neuroactive ligand-receptor interaction | GABRB2,TAAR13C,CCKBR,PTGER4C,CHRNB3A,TAAR12B,PRP2,GABRR3A,GRIK4,GRM6 |
| Activation of Nicotinic Acetylcholine Receptors | CHRNA3,CHRNB4,CHRNA4,CHRNB2,CHRNA7,CHRNA1,CHRND,CHRNE,CHRNA2 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | NSFB,AKAP5,PICK1,CHRNE,CHRNA2,GRIP1,CAMKK1B,MYO6,DLG1L,NCALDA |
Protein Function
CHRNA5 has several biochemical functions, for example, contributes_to acetylcholine binding,acetylcholine receptor activity,acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA5 itself. We selected most functions CHRNA5 had, and list some proteins which have the same functions with CHRNA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylcholine-activated cation-selective channel activity | CHRNA7,CHRNB2,CHRNB1L,CHRNB3B,Chrng,CHRNE,CHRNA3,CHRNB3,CHRNA2,CHRNA10A |
| contributes_to acetylcholine binding | CHRNB3B,ZACN,CHRNA3,CHRNA2,CHRNA4,CHRNA2A,CHRNB1,CHRNA4B,CHRNA9,CHRND |
| acetylcholine receptor activity | CHRNA2,CHRNA3,ANXA9,CHRNE,CHRNA6,CHRNA4,CHRNB2,CHRNA7,CHRNB4 |
| protein heterodimerization activity | KATNA1,ADD1,UGT1A6A,KCNB2,TAF6L,CENPW,F11R.1,MCL1B,HIST1H4F,JDP2 |
| ligand-gated ion channel activity | CHRNB2,CHRNA3,ZACN,GABRB1,TRPA1A,CHRNB1,P2RX2,CHRNB4,CHRNA4,Chrng |
| protein binding | DSN1,PTPN6,TMSB10,MYO18A,LYN,CLTA,PDGFA,NAIF1,SMC6,WAPAL |
Interacting Protein
CHRNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA5.
CHRNB2;SRPK2;CHRNA3
Resources
Related Services
Related Products
References
- Schneider, KK; Hulsse, L; et al. Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed. NEUROREPORT 26:186-191(2015).
- Gelernter, J; Kranzler, HR; et al. Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans. BIOLOGICAL PSYCHIATRY 77:493-503(2015).
