CHM
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Official Full Name
choroideremia (Rab escort protein 1) -
Overview
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
CHM;choroideremia (Rab escort protein 1);DXS540, TCD;rab proteins geranylgeranyltransferase component A 1;REP 1;rab escort protein 1;choroideraemia protein;Rab geranylgeranyltransferase component A;TCD;GGTA;REP-1;DXS540;HSD-32;FLJ38564;MGC10
Recombinant Proteins
- Fish
- Zebrafish
- Rat
- Chicken
- Human
- E.coli
- Mammalian Cells
- HEK293
- Non
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| chm-726F |
Active Recombinant Fish chm Protein
|
E.coli | Fish | Non |
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| CHM-11577Z | Recombinant Zebrafish CHM | Mammalian Cells | Zebrafish | His |
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| CHM-1375R | Recombinant Rat CHM Protein | Mammalian Cells | Rat | His |
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| CHM-2791C | Recombinant Chicken CHM | Mammalian Cells | Chicken | His |
|
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| CHM-1033R | Recombinant Rat CHM Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CHM-1033R-B | Recombinant Rat CHM Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| CHM-1919H | Recombinant Human CHM Protein (1-653 aa), His-tagged | E.coli | Human | His | 1-653 aa |
|
Involved Pathway
CHM involved in several pathways and played different roles in them. We selected most pathways CHM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CHM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CHM has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CHM itself. We selected most functions CHM had, and list some proteins which have the same functions with CHM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CHM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHM here. Most of them are supplied by our site. Hope this information will be useful for your research of CHM.
Resources
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References
- Bovet, J; Pineau-Vincent, F; et al. ADAMTS13 and thrombotic thrombocytopenic purpura Retrospective study at the hospital of Le Mans. ANNALES DE BIOLOGIE CLINIQUE 72:321-330(2014).
- Miura, S; Kondo, J; et al. The N- Terminal Cleavage of Chondromodulin-I in Growth- Plate Cartilage at the Hypertrophic and Calcified Zones during Bone Development. PLOS ONE 9:-(2014).
