CHKA
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Official Full Name
choline kinase alpha -
Overview
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
CHKA;choline kinase alpha;CK;EK;CHK;CKI;CHETK-alpha;ethanolamine kinase
Recombinant Proteins
- Human
- Rat
- Zebrafish
- P.falciparum
- Mouse
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHKA-1240H | Recombinant Human CHKA Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CHKA-1373R | Recombinant Rat CHKA Protein | Mammalian Cells | Rat | His |
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| CHKA-26903TH | Recombinant Human CHKA | Wheat Germ | Human | Non | 457 amino acids |
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| CHKA-3986Z | Recombinant Zebrafish CHKA | Mammalian Cells | Zebrafish | His |
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| CHKA-5269H | Recombinant Human CHKA Protein | E.coli | Human | Non | Full L. |
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| CHKA-5270P | Recombinant P. falciparum CHKA Protein | E.coli | P.falciparum | Non | Full L. |
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| CHKA-65H | Recombinant Human CHKA, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| CHKA-7535HCL | Recombinant Human CHKA 293 Cell Lysate | HEK293 | Human | Non |
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| CHKA-1031R | Recombinant Rat CHKA Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| CHKA-1031R-B | Recombinant Rat CHKA Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Chka-1659M | Recombinant Mouse Chka protein, His & GST-tagged | E.coli | Mouse | GST&His | Met1~Glu250 |
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| CHKA-3201HF | Recombinant Full Length Human CHKA Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 457 amino acids |
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| CHKA-5412H | Recombinant Human CHKA Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| CHKA-77HF | Recombinant Full Length Human CHKA Protein | In Vitro Cell Free System | Human | Full L. 457 amino acids |
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| CHKA-8874HFL | Recombinant Full Length Human CHKA, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| Chka-889M | Recombinant Mouse Chka Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
CHKA involved in several pathways and played different roles in them. We selected most pathways CHKA participated on our site, such as Acetylcholine Synthesis,Choline metabolism in cancer,Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MDH1AA,ALDH3A2,PLB1,B3GNT3,MAN1A1,COX8A,PIP5K1A,ATP6V0E1,KMO,MCAT |
| Choline metabolism in cancer | PIP5K1C,PLD1,PLD2,NRAS,WASL,SLC5A7,PDGFRA,PIK3R1,RPS6KB2,PLA2G4F |
| Glycerophospholipid biosynthesis | DGAT1B,SLC44A5B,CHAT,PEMT,PLA2G16,CPNE1,BCHE,AWAT1,CEPT1,CPNE7 |
| Metabolism of lipids and lipoproteins | LMF1,AKR1C21,SLC27A2A,SACM1LB,FAAH2B,ARV1,GDF1,CYP2AD3,THEM5,MED23 |
| Glycerophospholipid metabolism | PEMT,AGPAT2,MBOAT2B,PLA2G15,PLA2G2A,LPIN2,PPAP2CB,PCYT1A,PLA2G6,LYCAT |
| Acetylcholine Synthesis | PEMT,CHAT |
| Metabolism | CYP27B1,ACY3.1,CYP2F1,MARCKSB,SLC25A15,SLC35D2,Gpc2,MAPK1IP1L,COX18,NUDT3 |
| Phospholipid metabolism | PNPLA8,PLD6,CEPT1,CDS1,PITPNB,ABHD4,DGAT1B,SACM1LA,AWAT1,TPTE |
Protein Function
CHKA has several biochemical functions, for example, ATP binding,choline binding,choline kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHKA itself. We selected most functions CHKA had, and list some proteins which have the same functions with CHKA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | BCL2L1,PTPRO,NKX2,PYGL,TCF12,STK10,ENPP1,NADKD1,VEGFB,DNTTIP1 |
| choline binding | BCHE,SLC5A7,CRP |
| drug binding | GPR30,HTR1B,TLR7,ABP1,GSTP2,MT2A,PPARD,FOLR1,PNP,P2RX4 |
| signal transducer activity | GNAO1B,GHRHRL,MRGPRH,TAS1R2.2,OLFR11,EDNRBA,VMN1R47,PLCXD3,NPFFR1L3,GPR15 |
| ATP binding | THRAP3,SMYHC2,TRP53,UBE2I,ABCB4,UBE2D4,HSPD1,ATP2B3A,HIPK3B,MYH1B |
| choline kinase activity | CHKB |
| cholinesterase activity | CELL,ACHE,BCHE,CEL.1 |
| ethanolamine kinase activity | ETNK2,ETNK1,CHKB |
Interacting Protein
CHKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHKA here. Most of them are supplied by our site. Hope this information will be useful for your research of CHKA.
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References
- Gaillard, F; Kuny, S; et al. Retinal distribution of Disabled-1 in a diurnal murine rodent, the Nile grass rat Arvicanthis niloticus. EXPERIMENTAL EYE RESEARCH 125:236-243(2014).
- Kalashnyk, O; Lykhmus, O; et al. alpha 7 Nicotinic acetylcholine receptor-specific antibody stimulates interleukin-6 production in human astrocytes through p38-dependent pathway. INTERNATIONAL IMMUNOPHARMACOLOGY 23:475-479(2014).
