CHEK2
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Official Full Name
checkpoint kinase 2 -
Overview
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] -
Synonyms
CHEK2;checkpoint kinase 2;CDS1;CHK2;LFS2;RAD53;hCds1;HuCds1;PP1425;serine/threonine-protein kinase Chk2;cds1 homolog;CHK2 checkpoint homolog;checkpoint-like protein CHK2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Insect Cells
- E.coli
- Mammalian Cells
- Wheat Germ
- Sf9 Cells
- S.frugiperda
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- GST
- GST&His
- Flag
- His
- Non
- DDK&Myc
- Avi&Fc&His
Involved Pathway
CHEK2 involved in several pathways and played different roles in them. We selected most pathways CHEK2 participated on our site, such as Cell Cycle,Cell Cycle Checkpoints,DNA Double Strand Break Response, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHEK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Double Strand Break Response | FAM175A,EYA4,KDM4B,BARD1,THRSP,EYA3,HTATIP,EYA2,RNF168,KDM4A |
| DNA Double-Strand Break Repair | CLSPN,PARP1,RAD9B,UBE2V2,HUS1,RAD50,RAD17,EME1,RTEL1,CHEK1 |
| FOXM1 transcription factor network | FOXM1,CKS1B,CENPA,CENPB,AURKB |
| DNA damage response | TLK2,RAD17,CDK5,GADD45A,RAD9A,RAD1,DDB2,HUS1B,GADD45G |
| DNA Repair | TOPBP1,INO80,MGMT,BAZ1B,TP53BP1,DCLRE1A,DDB1,ASCC2,SMARCA5,USP43 |
| Cell Cycle Checkpoints | UIMC1,YWHAQ,HIST3H2BB,RAD50,FAM175A,MCM8,RAD9,RAD1,UBE2V2,BRCC3 |
| Cell cycle | NUDC,NIPBLB,ODF2,SMC1B,CDC14A,YWHAQ,CDKN2B,TOP2A,CTDNEP1A,TERF2IP |
Protein Function
CHEK2 has several biochemical functions, for example, ATP binding,identical protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHEK2 itself. We selected most functions CHEK2 had, and list some proteins which have the same functions with CHEK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SETX,RABAC1,TMEM173,RIPK1,IRF3,MYOM1,TOPBP1,DAAM1,DESI1,CRYAB |
| metal ion binding | SCRT1A,CLEC4M,Trl,ANKIB1A,ZNF143B,BMP1B,ATP2B1B,ZFP579,MEP1A.2,PVALB8 |
| protein binding | BBS1,PRKAR2A,ACVR1,SNAI1,IFI16,STK3,ALDH3B1,ERH,PCID2,EFNB2 |
| ubiquitin protein ligase binding | CUL5A,RPA3,TNFRSF1B,UBOX5,HSPA1L,MID1,MC1R,GABARAP,UBE2K,UBE2NA |
| protein serine/threonine kinase activity | PAK4,PHKG1A,ADCK1,SLKA,ROCK2,PRKCB,TNNI3K,PRKCE,PASK,NLK2 |
| ATP binding | DDX39,TP53RK,CDC34A,RAD54B,CSNK2A1,DNAJA3B,PNKP,SPO11,PFKL,CDC6 |
| protein homodimerization activity | ZHX3,IZUMO3,SIAH1A,DGAT2,TESCA,TBX15,GOLGA5,GLA,CHMP1A,STOM |
| protein kinase binding | LCK,DAXX,AP2A1,PXN,THY1,FOXO3,PRKCZ,DLG1,SHC4,CDC25A |
Interacting Protein
CHEK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHEK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHEK2.
MDM2;TP53;XRCC1
Resources
Research Area
Cancer Drug TargetsTumor Suppressors
Intracellular Kinases in the Akt Pathway
DNA Damage and Repair
Checkpoint Kinases
G1 (Restriction) Checkpoints
G2/M (DNA Damage) Checkpoints
Related Services
Related Products
References
