CHD6
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Official Full Name
chromodomain helicase DNA binding protein 6 -
Overview
Chromosomal DNA of eukaryotic cells is compacted by nuclear proteins to form chromatin, an organized nucleoprotein structure that can inhibit gene expression. Several multisubunit protein complexes exist to remodel the chromatin to allow patterns of cell type-specific gene expression. The protein encoded by this gene is thought to be a core member of one or more of these complexes. The encoded protein, which is a member of the SNF2/RAD54 helicase family, contains two chromodomains, a helicase domain, and an ATPase domain. -
Synonyms
CHD6;chromodomain helicase DNA binding protein 6;chromodomain-helicase-DNA-binding protein 6;CHD5;dJ620E11.1;FLJ22369;KIAA1335;RIGB;ATP dependent helicase CHD6;ATP-dependent helicase CHD6;CHD-6;CHD6_HUMAN;Radiation induced gene B protein;Radiation-induced gene B protein;RP4-620E11.2;OTTHUMP00000031013;helicase C-terminal domain- and SNF2 N-terminal domain-containing protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHD6-3381M | Recombinant Mouse CHD6 Protein | Mammalian Cell | Mouse | His |
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| CHD6-1633M | Recombinant Mouse CHD6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CHD6-1633M-B | Recombinant Mouse CHD6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
CHD6 involved in several pathways and played different roles in them. We selected most pathways CHD6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CHD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CHD6 has several biochemical functions, for example, ATP binding,ATP-dependent helicase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHD6 itself. We selected most functions CHD6 had, and list some proteins which have the same functions with CHD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleic acid binding | FTSJD2,ARPP21,AGO3B,SALL3B,SSX3,ZEB1B,KLF12B,ZFP628,EXD1,NYNRIN |
| hydrolase activity | ATP2B1A,MPPED2A,PRSS41,CHD1L,ATP2B1,Aadacl3,ENTPD7,CAPN5A,CASPBL,KLK13 |
| DNA-dependent ATPase activity | MSH2,XRCC3,MSH4,SMARCA2,DMC1,TOP2A,IGHMBP2,SMARCAL1,XRCC2,RAD51C |
| transcription cofactor binding | KLF4,TRP53,FOXO3 |
| helicase activity | EIF4A2,PIF1,SMARCA2,EIF4A1,DDX3,CHD7,DHX32A,HELLS,GTF2F2A,UPF1 |
| ATP binding | TLK1B,TWF1,DAPK3,AXL,ADCK1,ABCA4,CAMK1G,CDK17,FAM120B,G3BP1 |
| DNA binding | LHX1B,ZFP641,YEATS4,PEG10,CASZ1,FOXF2A,MYCB,TGIF2LY,HLFB,ZNF131 |
| nucleotide binding | NLK1,RBMS2,RALAA,MYHC4,STK25B,SRSF9,HNRPLL,CAMK1DB,HELZ,RHOGD |
| ATP-dependent helicase activity | TTF2,BLM,SNRNP200,RTEL1,RECQL5,CHD4A,DHX36,ERCC6L2,DHX37 |
Interacting Protein
CHD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHD6.
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References
- Thomas, RH; Zhang, LM; et al. CHD2 myoclonic encephalopathy is frequently associated with self-induced seizures. NEUROLOGY 84:951-958(2015).
- Yamada, M; Sato, N; et al. Association of the Chromodomain Helicase DNA-Binding Protein 4 (CHD4) Missense Variation p.D140E with Cancer: Potential Interaction with Smoking. GENES CHROMOSOMES & CANCER 54:122-128(2015).
