CFTR
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Official Full Name
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -
Overview
CFTR (ABC35, ABCC7, CBAVD, CF, dj760C5.1, MRP7, TNR-CFTR) is a member of the ATP-binding cassette (ABC) transporter superfamily. Mutations in ABC genes have been linked to many diseases. CFTR is a plasma membrane cyclic AMP activated chloride channel that -
Synonyms
CFTR;cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7);ABCC7, CF, cystic fibrosis transmembrane conductance regulator, ATP binding cassette (sub family C, member 7);cystic fibrosis transmembrane conducta
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&StrepII&EGFP
- His&Fc&Avi
- His&StrepII
- His&Flag
- His&GST
Involved Pathway
CFTR involved in several pathways and played different roles in them. We selected most pathways CFTR participated on our site, such as ABC transporter disorders,ABC transporters,ABC-family proteins mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | PPARGC1A,FBP2,FBP1,RAB2A,PRKAA2,GYS2,TSC2,TBC1D1,PRKAG1,ACACA |
| ABC transporters | ABCB1,SUR2A,ABCB6,ABCC11,TAP2,ABCG3,ABCB4,ABCA3,ABCA1B,ABCA1 |
| Disease | PACS1,DPF1,SUPT5H,CPSF6,FGFR1OP,NPM1,CHMP4C,STRA6,RBP1,EEF2 |
| Bile secretion | SLCO1A6,ADCY8,FXYD2,SLC9A3,ATP1B2,ADCY6,SLCO1B1,OSTB,SLC2A1,SCTR |
| Disorders of transmembrane transporters | GCKR |
| ABC-family proteins mediated transport | ABCG4B,ABCF1,ABCA7,ABCC9,ABCD3B,ABCC2,ABCE1,ABCA4A,APOA1B,EIF2S1 |
Protein Function
CFTR has several biochemical functions, for example, ATP binding,ATP-binding and phosphorylation-dependent chloride channel activity,PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CFTR itself. We selected most functions CFTR had, and list some proteins which have the same functions with CFTR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | SSTR2,ATP2B1A,LIN7B,SNTA1,ADRB1,KIDINS220B,LNX1,FZD7,FZD8,CLCN3 |
| chloride channel inhibitor activity | VTI1B,STX8,VAMP8,WNK1,STX7,STX1A |
| bicarbonate transmembrane transporter activity | SLC26A5,SLC26A4,SLC26A9,SLC26A2,SLC4A1,SLC26A1,SLC26A11,SLC26A7,SLC26A3,SLC26A3.2 |
| ATP binding | MAPK14B,PPP1CA,PKDCCA,APAF1,UBE2D2A,PPP2R4,TEP1,NEK10,LARS2,MYH4 |
| enzyme binding | TSPAN5,EIF2AK3,PUS7,TSPAN15,MSH2,PHB,CBX1,NOTCH3,MLL5,PRKCE |
| protein binding | GTF2H3,CEP76,DYNLL1,TNFAIP8,PODXL2,HIST1H3A,SNRPN,KIAA1279,ANTXR1,SPDL1 |
| chloride transmembrane transporter activity | SLC26A3,SLC4A1,SLC26A6,SLC26A4,Slc4a2,SLC26A1 |
| chloride channel activity | CLCA4,SLC26A5,CLIC6,GRAP2,CLIC5B,CLCN7,CLCN3,GABRA6A,CLIC5,CLCC1 |
Interacting Protein
CFTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFTR here. Most of them are supplied by our site. Hope this information will be useful for your research of CFTR.
SLC9A3R1;SLC9A3R2;CANX;PPP2R1A
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References
- Palomo, J; Marchiol, T; et al. Role of IL-1 beta in Experimental Cystic Fibrosis upon P. aeruginosa Infection. PLOS ONE 9:-(2014).
- Pruliere-Escabasse, V; et al. Rhinitis investigations in children: When and how to investigate. REVUE FRANCAISE D ALLERGOLOGIE 54:566-569(2014).
