CFP
-
Official Full Name
Complement Factor P -
Overview
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
complement factor properdin;BFD;PFC;PFD;CFP;properdin;OTTHUMP00000216155;OTTHUMP00000023223;properdin P factor,complement;complement factor P
Recombinant Proteins
- E.coli
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Cyan
- Rat
- E.coli
- Human Serum
- Wheat Germ
- Mammalian Cells
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- Non
- GST
- His&T7
- His&Myc
Involved Pathway
CFP involved in several pathways and played different roles in them. We selected most pathways CFP participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | PER3,MHC1UEA,TAF5,NFKBIB,IKBKB,IFNA16,MAPK10,CSNK2A2A,C3A.2,SFRS3B |
Protein Function
CFP has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CFP itself. We selected most functions CFP had, and list some proteins which have the same functions with CFP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CFP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFP here. Most of them are supplied by our site. Hope this information will be useful for your research of CFP.
q9wmx2-pro_0000037548
Resources
Related Services
Related Products
References
- Fonseca, DM; Wowk, PF; et al. Requirement of MyD88 and Fas pathways for the efficacy of allergen-free immunotherapy. ALLERGY 70:275-284(2015).
- Hur, YG; Kim, A; et al. Evaluation of Antigen-Specific Immunoglobulin G Responses in Pulmonary Tuberculosis Patients and Contacts. JOURNAL OF CLINICAL MICROBIOLOGY 53:904-909(2015).
