CEP57
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Official Full Name
centrosomal protein 57kDa -
Overview
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
CEP57;centrosomal protein 57kDa;centrosomal protein of 57 kDa;KIAA0092;Translokin;TSP57;Cep57 protein;FGF2 interacting protein;PIG8;Proliferation inducing protein 8;Testis specific protein 57;OTTHUMP00000236690;OTTHUMP00000236691;OTTHUMP00000236698;FGF2-interacting protein;testis-specific protein 57;proliferation-inducing protein 8;MVA2
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
CEP57 involved in several pathways and played different roles in them. We selected most pathways CEP57 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEP57 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Anchoring of the basal body to the plasma membrane | DCTN3,CC2D2A,DCTN1,HAUS2,FBF1,NEK2,CCDC41,CEP76,TMEM67,RAB3IP |
| Loss of Nlp from mitotic centrosomes | NINL,HAUS2,CEP290,CP110,CKAP5,MAPRE1B,OFD1,ODF2B,CEP164,CEP76 |
| Loss of proteins required for interphase microtubule organizationfrom the centrosome | DCTN1A,SSNA1,CKAP5,CEP72,HAUS2,MAPRE1,CEP164,SDCCAG8,MAPRE1B,CEP135 |
| Assembly of the primary cilium | BBS1,RABL5,BBS2,B9D1,TMEM216,KIF3CB,PROL1,TRAF3IP1,IQCB1,CEP290 |
| G2/M Transition | TSGA14,CEP78,CEP290,CEP70,LIN52,TUBG1,BORA,ACTR1A,CEP76,ODF2 |
| Cell cycle | ARPP19A,MCM5,TUBG1,UIMC1,CENPE,RAD21B,DCTN3,BRE,TRP53,HDAC5 |
| Cell Cycle, Mitotic | MYCA,GINS2,NEK7,E2F2,CEP135,SPDL1,E2F4,STIL,CNEP1R1,DCTN1 |
| Centrosome maturation | DYNC1I2,TUBGCP5,CEP78,CEP152,OFD1,CKAP5,ACTR1A,CEP164,MAPRE1,NDE1 |
Protein Function
CEP57 has several biochemical functions, for example, fibroblast growth factor binding,gamma-tubulin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CEP57 itself. We selected most functions CEP57 had, and list some proteins which have the same functions with CEP57. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RHEBL1,OPRK1,SEC23A,PTPN13,HPSE,SUFU,HM13,AREG,AXIN1,ZNF302 |
| protein homodimerization activity | DSCAML1,ERP29,CAMK2D,RELA,ABCG1,CLN6,DRD2,BMPR1A,NR4A3,Il6ra |
| fibroblast growth factor binding | S100A13,FGFR1,FGFRL1,FGFBP1,GLG1,PTPRZ1,RPS19,KLB,FGFR3,RPS2 |
| gamma-tubulin binding | LYN,SPATC1,NDRG1,OFD1,B9D2,RAD51L3,FEZ1,TUBGCP2,NME2,PDE4B |
| microtubule binding | WHAMM,APC2,GABARAP,MAPRE3A,KIF4A,NDEL1B,HAUS8,LC3,JAKMIP2,MTUS2 |
Interacting Protein
CEP57 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEP57 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEP57.
RALBP1;GCC1;KRT13;CTAGE5;KRT15;KRT31
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References
- de Sousa, JT; Milan, M; et al. A Microarray-Based Analysis of Gametogenesis in Two Portuguese Populations of the European Clam Ruditapes decussatus. PLOS ONE 9:-(2014).
- Pinson, L; Mannini, L; et al. CEP57 Mutation in a Girl With Mosaic Variegated Aneuploidy Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164:177-181(2014).
