CENPL
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Official Full Name
centromere protein L -
Overview
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) -
Synonyms
CENP-L;C1orf155;dJ383J4.3;RP3-383J4.1;centromere protein L
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CENPL involved in several pathways and played different roles in them. We selected most pathways CENPL participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Chromosome Maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | MDM2,ORC3L,DBF4,KIF2A,TTK,NUF2,PCM1,CHEK1,SYNE1,MCM2 |
| Deposition of new CENPA-containing nucleosomes at the centromere | RBBP4,CENPP,CENPK,OIP5,CENPN,CENPO,APITD1,CENPQ,CENPI,CENPA |
| Mitotic Metaphase and Anaphase | VRK2,PDS5A,INCENP,SGOL2,CENPP,ZWINT,CENPI,CDCA5,KNTC1,CENPE |
| Mitotic Anaphase | SKA2,NSL1,LEMD3,SPC25,ITGB3BP,KNTC1,RCC2,ZWILCH,NDEL1,CDCA5 |
| Mitotic Prometaphase | CENPK,MIS12,WAPAL,CENPQ,NDEL1A,MLF1IP,NSL1,RCC2,CENPI,CDCA8 |
| Chromosome Maintenance | CENPK,DKC1,OIP5,MLF1IP,POT1A,RBBP7,ITGB3BP,DNA2,CENPQ,WRAP53 |
| M Phase | CENPN,NUDC,KNTC1,SETB,PANE1,ENSAB,ZWINT,B9D2,VRK2,CENPQ |
| Cell Cycle, Mitotic | AHCTF1,CTDNEP1A,DHFR,ODF2,CENPJ,CDCA5,RANGAP1B,CENPK,CDKN2B,NDE1 |
Protein Function
CENPL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPL itself. We selected most functions CENPL had, and list some proteins which have the same functions with CENPL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LRRFIP1,FLVCR1,PRMT6,IGFBP2,SPANXA1,PCK2,SYT4,CCL28,FIS1,FOXJ2 |
Interacting Protein
CENPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPL here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPL.
FAM9B;JMJD6;Cenph
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References
- Dunemann, F; Schrader, O; et al. Characterization of Centromeric Histone H3 (CENH3) Variants in Cultivated and Wild Carrots (Daucus sp.). PLOS ONE 9:-(2014).
- Saito, A; Muro, Y; et al. Low prevalence of autoantibodies to CENP-H, -I, -K, -L, -M, -N, -T and -U in a Japanese cohort of anti-centromere positive samples. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 35:57-63(2013).
