CDK5RAP2

  • Official Full Name

    CDK5 regulatory subunit associated protein 2

  • Overview

    CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly.

  • Synonyms

    CDK5RAP2;CDK5 regulatory subunit associated protein 2;MCPH3, microcephaly, primary autosomal recessive 3;CDK5 regulatory subunit-associated protein 2;C48;CEP215;FLJ10867;centrosomal protein 215 kDa;centrosome-associated protein 215;CDK5 activator-binding protein C48;MCPH3;KIAA1633;DKFZp686B1070;DKFZp686D1070
Cat.# Product name Source (Host) Species Tag Protein Length Price
CDK5RAP2-3208M Recombinant Mouse CDK5RAP2 Protein Mammalian Cells Mouse His
CDK5RAP2-1529M Recombinant Mouse CDK5RAP2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CDK5RAP2-1529M-B Recombinant Mouse CDK5RAP2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    CDK5RAP2 involved in several pathways and played different roles in them. We selected most pathways CDK5RAP2 participated on our site, such as Activation of BAD and translocation to mitochondria,Activation of BH3-only proteins,Anchoring of the basal body to the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5RAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle Checkpoints RAD9B,KAT5,RAD50,RAD9A,BRCC3,CLSPN,CDK2,FAM175A,DBF4,UIMC1
    Activation of BH3-only proteins DYNLL2,BCL2L11,AKT3,YWHAQ,E2F1
    Apoptosis PIK3R3B,PRKAR2A,SATB1,PRKAR1AB,DBNLA,RELA,NFKB1,PPP3R1,PRKACBB,PPP3R1B
    Assembly of the primary cilium RAB3IP,BBS4,CCT4,TTC30B,CEP135,SETD6,CCT5,CCDC41,KIF3A,IFT80
    Activation of BAD and translocation to mitochondria YWHAQ,AKT3
    Cell cycle PKMYT1,SDCCAG8,FZR1A,SYCE1,DNA2,GADD45A,RBX1,TUBB4A,CDKN2A,WEE1
    Cell Cycle, Mitotic PCM1,SMC2,CEP57,DYNC1H1,STAG1,PDS5A,DNA2,BANF1,CENPE,CENPQ
    Anchoring of the basal body to the plasma membrane TUBB4A,CEP135,ACTR1A,ODF2B,DCTN1A,MAPRE1A,CEP290,NPHP4,TCTN1,HAUS2

    Protein Function

    CDK5RAP2 has several biochemical functions, for example, calmodulin binding,microtubule binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5RAP2 itself. We selected most functions CDK5RAP2 had, and list some proteins which have the same functions with CDK5RAP2. You can find most of the proteins on our site.

    Function Related Protein
    transcription regulatory region DNA binding SMAD3,ZNF567,MEF2C,AHR,BRD7,NFKB1,ERBB4,ZNF335,ATF5,FOXA1
    protein kinase binding NEFH,GATA6,SLC12A5,ADIPOR1,PRC1,PEBP1,CCNB1,CD3E,RAD9,MAML1
    tubulin binding GPAA1,EML2,STMN1,ATF5,PARK2,CLIP1,TTLL6,RABGAP1,RPS3,MTAP7D3
    microtubule binding DNM2,MAPRE2,KIF11,NDEL1A,KIF15,KATNAL1,KIFC2,CEP350,DPYSL5A,ZNF207
    calmodulin binding CAMK1D,SLC8A2,UPF3B,NETO2,IQGAP3,KCNN1,SNTB2,MYH11,TRPM4,MYO3A
    protein complex binding RAD18,FADD,STRN,TXN2,MLC1,GNB4,RAP1B,CDK4,STK11,PTPRF

    Interacting Protein

    CDK5RAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5RAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5RAP2.

    TBC1D31;PCM1;PDE4DIP;SEC16A;SIPA1L3;PCNT;PRKAR2A;PRKACA;PRKACB;DYNLL1;PCM1;KIAA0753;CEP170;MIB1;AKAP9;MYO10;CEP72;RRBP1;PGAP2;CEP131

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