CDH7
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Official Full Name
cadherin 7, type 2 -
Overview
This gene is a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures. Alternative splicing in the 5 UTR of this gene yields variant transcripts encoding the same protein. -
Synonyms
CDH7;cadherin 7, type 2;cadherin-7;CDH7L1
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- CHO
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
CDH7 involved in several pathways and played different roles in them. We selected most pathways CDH7 participated on our site, such as Adherens junctions interactions,Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell-cell junction organization | CADM2,CTNND1,CDH18A,CDH10,JUP,INADL,CDH13,PVRL2L,PVRL1A,CDH18 |
| Cell-Cell communication | TESK1,DST,CD151,PVRL2L,CLDN7,ITGB1B.1,CDH11,CDH18A,CDH12A,DSCAML1 |
| Adherens junctions interactions | CADM2,CTNND1,PVRL2L,CDH6,CDH8,CTNNA1,PTBP3,CDH24,CADM2A,CDH5 |
| Neural Crest Differentiation | HOXA1,DLL3,TCF4,LHX2,CDH6,TXLNB,MBP,TBX6,HEY2,SOX5 |
| Cell junction organization | CDH11,JUPA,CDH5,PVRL2L,TESK1,CADM2A,JUP,LIMS1,F11R.2,COL17A1A |
Protein Function
CDH7 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH7 itself. We selected most functions CDH7 had, and list some proteins which have the same functions with CDH7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | SCUBE2,EPS15L1,CALML3,PKD1L2,PCDHGA1,PLCG1,PCDH2AB3,PLS3,PCDHA9,DLB |
Interacting Protein
CDH7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH7.
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References
- Mizuuchi, Y; Aishima, S; et al. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. LABORATORY INVESTIGATION 95:193-206(2015).
- Yoshida, T; Kato, J; et al. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. INTERNATIONAL JOURNAL OF CANCER 134:1445-1457(2014).
