CDH12

  • Official Full Name

    cadherin 12, type 2 (N-cadherin 2)

  • Overview

    This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

  • Synonyms

    CDH12;cadherin 12, type 2 (N-cadherin 2);cadherin-12;Br cadherin;CDHB;Br-cadherin;N-cadherin 2;brain cadherin;brain-cadherin;neuronal cadherin 2;neural type cadherin 2;cadherin, neural type, 2;FLJ34857

Recombinant Proteins

  • Human
  • Mouse
  • Human Cell
  • Wheat Germ
  • Mammalian Cell
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CDH12-2230H Recombinant Human CDH12, His tagged Human Cell Human His 1-605 a.a.
CDH12-0973H Recombinant Human CDH12 Protein, GST-Tagged Wheat Germ Human GST
CDH12-26803TH Recombinant Human CDH12 Wheat Germ Human Non 99 amino acids
CDH12-3165M Recombinant Mouse CDH12 Protein Mammalian Cell Mouse His
CDH12-2625HCL Recombinant Human CDH12 cell lysate Human Cell Human Non
CAB11506MH Mouse Anti-Human Cadherin 12, Type 2 Monoclonal Antibody Mouse Human Non
CDH12-1256H Recombinant Human CDH12 Protein (56-605 aa), His-tagged E.coli Human His 56-605 aa
CDH12-1311H Recombinant Human CDH12 Protein (Phe421-Lys535), N-His tagged E.coli Human His Phe421-Lys535
CDH12-1503M Recombinant Mouse CDH12 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
CDH12-1503M-B Recombinant Mouse CDH12 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CDH12-2177H Recombinant Human CDH12 protein, His-tagged HEK293 Human His Met1-Ala605
CDH12-3136HF Recombinant Full Length Human CDH12 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 794 amino acids
RFL21784HF Recombinant Full Length Human Cadherin-12(Cdh12) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (55-794)

    Involved Pathway

    CDH12 involved in several pathways and played different roles in them. We selected most pathways CDH12 participated on our site, such as Adherens junctions interactions,Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell-cell junction organization CADM2A,CLDN4,CDH17,CLDN16,CLDN7,CDH7,CDH3,CDH18,CDH8,CDH12A
    Adherens junctions interactions CDH2,CDH3,CDH9,JUPA,CDH7,JUP,PTBP3,CDH10,CDH12A,PVRL2L
    Cell junction organization CLDN16,CADM2B,CDH5,PLECA,PARVB,CDH12A,CDH18A,CDH7,CDH2,PVRL2L
    Cell-Cell communication DSCAML1,JUPA,CADM2,SPTBN1,CDH6,KIRREL,CDH10,PLEC,CDH9,COL17A1A

    Protein Function

    CDH12 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH12 itself. We selected most functions CDH12 had, and list some proteins which have the same functions with CDH12. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding ANXA7,PCDH1G26,GUCA1G,RAB11FIP4,CIB1,PCDH2AB5,NCAN,PCDH2G1,CIB3,S100A13

    Interacting Protein

    CDH12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH12.

    IGHG1

    Resources

    Research Area

    Early Mesodermal Lineage Markers
    Synaptic Adhesion Molecules
    Synaptic Proteins
    Mesenchymal Stem Cell Markers
    Adherens Junction Proteins in VSMC
    Mesenchymal Cells and EMT
    Neural Stem Cell Markers
    Cadherin Superfamily
    Ectodermal Lineage Markers
    Mesodermal Lineage Markers
    Cadherins

    References

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