CD1A
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Official Full Name
CD1a Molecule -
Overview
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. -
Synonyms
CD1A;CD1a molecule;R4;T6;CD1;FCB6;HTA1;Preferred Names;T-cell surface glycoprotein CD1a;Names;OTTHUMP00000018907;hTa1 thymocyte antigen;CD1A antigen, a polypeptide;cluster of differentiation 1 A;T-cell surface antigen T6/Leu-6;cortical thymocyte antigen CD1A;differentiation antigen CD1-alpha-3;epidermal dendritic cell marker CD1a
Recombinant Proteins
- Rhesus macaque
- Human
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cell
- Human Cells
- Mammalian cells
- E.coli expression system
- His
- GST
- Non
- Fc
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CD1A involved in several pathways and played different roles in them. We selected most pathways CD1A participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | CSF1R,CSF3,ITGA2,ITGA2B,CD33,IL1A,CD34,CD3E,CD37,CD38 |
Protein Function
CD1A has several biochemical functions, for example, beta-2-microglobulin binding,endogenous lipid antigen binding,exogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD1A itself. We selected most functions CD1A had, and list some proteins which have the same functions with CD1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | VAMP4,SULT1A1,BICD1,PNOC,FGD2,GIPC1,ABCG8,NUFIP1,SND1,PMF1 |
| endogenous lipid antigen binding | CD1D2,CD1d1,CD1D,CD1E,CD1C,CD1B |
| lipopeptide binding | CD1E,CD1B,CD1D2,CD1C,CD1d1,CD1D,TLR6 |
| beta-2-microglobulin binding | HLA-A,HFE,CD1E,FCGRT,CD1C,CD1D2,HLA-E,CD1B,H2-Q10,CD1D |
| exogenous lipid antigen binding | CD1D2,CD1D,CD1E,CD1d1,CD1B,CD1C |
Interacting Protein
CD1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CD1A.
B2M;DGAT1;UBTD1;KCTD5
Resources
Research Area
Epithelial Cell Markers and Intracellular MoleculesConventional/Classical Dendritic Cells
Langerhans and Dermal Dendritic Cells
T Cell Antigen Recognition
Related Services
Related Products
References
- Raheja, A; Sinha, S; et al. A Case of Giant Intracranial Tuberculoma in an Infant: Clinical and Radiologic Pitfalls. JOURNAL OF CHILD NEUROLOGY 30:364-367(2015).
- Birkinshaw, RW; Pellicci, DG; et al. alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands. NATURE IMMUNOLOGY 16:258-U215(2015).
