CCT5
-
Official Full Name
chaperonin containing TCP1, subunit 5 (epsilon) -
Overview
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex;(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each;containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in;an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional;splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three;pseudogenes of this gene have been identified. -
Synonyms
CCT5;chaperonin containing TCP1, subunit 5 (epsilon);T-complex protein 1 subunit epsilon;KIAA0098;T-complex protein 1, epsilon subunit;CCTE;CCT-epsilon;TCP-1-epsilon
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- Cynomolgus
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
CCT5 involved in several pathways and played different roles in them. We selected most pathways CCT5 participated on our site, such as Assembly of the primary cilium,Association of TriC/CCT with target proteins during biosynthesis,BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chaperonin-mediated protein folding | CCT2,VBP1,CCT7,FBXW5,FBXW4,FBXW9,FBXL5,TUBB4B,CCT4,TUBA3D |
| Cargo trafficking to the periciliary membrane | CCT3,ARL3,RHOL,BBS2,CYS1,BBS1,ARF4,BBS12,EXOC5,SSTR3 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | TUBA3D,CCT7,CCT2,PFDN4,PFDN1,CCT3,TUBB4B,CCT8,TUBA1B,TUBB4A |
| Formation of tubulin folding intermediates by CCT/TriC | TCP1,TUBA3D,CCT7,CCT8,TUBB4B,CCT3,TUBA1B,CCT4,TUBB4A,CCT2 |
| Association of TriC/CCT with target proteins during biosynthesis | FBXW9,FBXW4,CCT8,CCT3,FBXL5,CCT6A,NOP56,KIFC3,TCP1,CCT7 |
| Assembly of the primary cilium | ARL13B,ODF2,BBS5,NPHP1,DYNC1H1,CCT8,FLR,EXOC1,TCTEX1D1,PCM1 |
| BBSome-mediated cargo-targeting to cilium | SSTR3,BBS12,BBS10,BBS9,TCP1,BBS2,CCT3,CCT8,RAB3IP,SETD6 |
| Folding of actin by CCT/TriC | CCT3,TCP1,CCT2,CCT4,CCT8,CCT6A,CCT7 |
Protein Function
CCT5 has several biochemical functions, for example, ATP binding,G-protein beta-subunit binding,beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT5 itself. We selected most functions CCT5 had, and list some proteins which have the same functions with CCT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | HSPA2,CLPXA,CANX,CLGN,DNAJB11,SRSF12,DNAJB4,DNAJB1B,TBCA,HSPA5 |
| protein binding | LRPPRC,SNTB2,STON2,NAV1,DZIP3,RAD51,KRTAP3-3,ARNTL,FCGR2A,EGLN2 |
| G-protein beta-subunit binding | RASD2,F2R,GNG13,RGS11,GNG2,RGS9,RGS7,OPRM1,F2RL1 |
| beta-tubulin binding | B4GALT1,IFT74,ARL8A,MAP1S,CASC1,BBS4,ARL8B,VAPB,PACRG,OST4 |
| ATP binding | PKDCCA,THG1L,MTOR,NEK4,DDX51,TRPV4,ROR1,PKLR,MKNK2,DNAH11 |
Interacting Protein
CCT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT5.
PPP4C;PPP2CB;PPP2CA;STRN3;ILK;TCP1;IKBKE;TP53
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