CCNK
-
Official Full Name
cyclin K -
Overview
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. -
Synonyms
CCNK;cyclin K;cyclin-K;CPR4;CCNK_HUMAN;CPR 4;CyclinK;MGC9113;OTTHUMP00000246203;OTTHUMP00000246205
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- E.coli
- Insect Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCNK-0677H | Recombinant Full Length Human CCNK Protein, GST-Tagged | Wheat Germ | Human | GST | Full L. 1-354 a.a. |
|
| CCNK-2872C | Recombinant Chicken CCNK | Mammalian Cells | Chicken | His |
|
|
| CCNK-6981H | Recombinant Full Length Human CyclinK, GST-tagged | Sf9 Cells | Human | GST | Full L. 1-354 a.a. |
|
| CCNK-7557Z | Recombinant Zebrafish CCNK | Mammalian Cells | Zebrafish | His |
|
|
| CCNK-306HCL | Recombinant Full Length Human CCNK cell lysate | Human | Non | Full L. 1-354 a.a. |
|
|
| CCNK-10H | Recombinant Full Length Human CCNK Protein (1-354 aa), His-tagged | E.coli | Human | His | Full L. 1-354 a.a. |
|
| CCNK-11H | Recombinant Human CCNK Protein (251-370 aa), His-tagged | E.coli | Human | His | 251-370 a.a. |
|
| CCNK-2207H | Recombinant Full Length Human CCNK protein, His-tagged | Insect Cells | Human | His | Full L. 1-354 a.a. |
|
| CCNK-2979H | Recombinant Full Length Human CCNK Protein, Flag-tagged | HEK293 | Human | Myc&DDK | Full L. 1-354 a.a. |
|
| CCNK-2980HF | Recombinant Full Length Human CCNK Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 1-354 a.a. |
|
| Ccnk-801M | Recombinant Mouse Ccnk Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
Involved Pathway
CCNK involved in several pathways and played different roles in them. We selected most pathways CCNK participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | PRDM1,CD82,DDX5,BNIP3L,EDN2,AIFM2,FDXR,BCL2L14,SMARCA4,DDB2 |
Protein Function
CCNK has several biochemical functions, for example, RNA polymerase II carboxy-terminal domain kinase activity,cyclin-dependent protein serine/threonine kinase activity,cyclin-dependent protein serine/threonine kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNK itself. We selected most functions CCNK had, and list some proteins which have the same functions with CCNK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II carboxy-terminal domain kinase activity | CDK7,MAPK1,CDK9,CDK1,CDK8,CDK12,CDK13 |
| protein binding | PDCD10,HSPB8,RBL2,LTBP1,CCP110,P2RX7,FAM127A,DVL3,CHMP2B,CHUK |
| cyclin-dependent protein serine/threonine kinase activity | CDKL4,CDK8,CDK4,CDK19,CDK10,CDK5,CDK6,CDK12,CDKL2,MOK |
| cyclin-dependent protein serine/threonine kinase regulator activity | CCNL1B,CCND1,CCNT1,CCNE1,CKS2,CKS1B,FAM58A,PSTPIP2,CCNT2,CCNE2 |
| protein kinase binding | NIPAL1,KAT2B,VRK1,GRB7,RAD9A,DUSP3,AURKA,HNRNPA0,DNAJC3,NBEA |
Interacting Protein
CCNK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNK here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNK.
RBPMS;BHLHE40;NDC80;AES;LZTS2;ATXN1;FKBP6;STX11
Resources
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References
- Reis, BS; Jungbluth, AA; et al. Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein. CLINICAL CANCER RESEARCH 19:6112-6125(2013).
- Lewis, CW; Taylor, RG; et al. A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes. FEBS LETTERS 587:3089-3095(2013).
