CCNE2

  • Official Full Name

    cyclin E2

  • Overview

    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.

  • Synonyms

    CCNE2;cyclin E2;G1/S-specific cyclin-E2;CYCE2

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • E.coli
  • Wheat Germ
  • Insect Cell
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • T7
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
CCNE2-10864H Recombinant Human CCNE2, GST-tagged E.coli Human GST 1-374a.a.
CCNE2-2774H Recombinant Human CCNE2 protein, His-tagged E.coli Human His 1-141 aa
CCNE2-3047H Recombinant Human CCNE2 protein, His-tagged E.coli Human His 1-374 aa
CCNE2-0667H Recombinant Human CCNE2 Protein, GST-Tagged Wheat Germ Human GST
CCNE2-180H Recombinant Human CCNE2 protein, GST-tagged Insect Cell Human GST
CCNE2-2634C Recombinant Chicken CCNE2 Mammalian Cell Chicken His
CCNE2-2918H Recombinant Human Cyclin E2, T7-tagged E.coli Human T7
CCNE2-307Z Recombinant Zebrafish CCNE2 Mammalian Cell Zebrafish His
CCNE2-7709HCL Recombinant Human CCNE2 293 Cell Lysate HEK293 Human Non
CCNE2-2972HF Recombinant Full Length Human CCNE2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 374 amino acids

    Involved Pathway

    CCNE2 involved in several pathways and played different roles in them. We selected most pathways CCNE2 participated on our site, such as Cell cycle,Oocyte meiosis,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Small cell lung cancer PIK3R1,LAMA3,NFKB1,IKBKG,BIRC8,ITGA2,PIK3CD,LAMA5,FHIT,PIK3CB
    Viral carcinogenesis HDAC1,HIST1H4D,LTBR,YWHAG,PIK3R3,CCND1,SP100,PMAIP1,CDK1,STAT5A
    Hepatitis B SMAD3,OSTN,AKT1,STAT2,TGFB1,IRF7,AKT2,IFNB1,IFNA21,PRKCG
    Prostate Cancer SMARCC2,CCND1,GSTP1,GRB2,PIK3CD,TGFA,NKX3-1,PIK3R2,PDGFA,BRAF
    MicroRNAs in cancer NOTCH1,DNMT3B,MMP16,RPTOR,PLCG1,PDGFA,DNMT3A,NOTCH4,CYP24A1,PDGFRA
    Pathways in cancer LAMC1,LAMA1,BAX,BCL2,ARAF,RAD51,FZD9,GNG5,MMP9,CYCS
    Oocyte meiosis CDC20,PPP1CAA,Adcy4,REC8,MAPK3,YWHAG1,PPP3R1B,INS,CALM3,FBXW11A
    p signaling pathway PMAIP1,SFN,BBC3,CCNG1,TSC2,CCNE1,IGF1,SHISA5,PTENB,PIDD1
    PIK-Akt signaling pathway RPS6KB2,IFNA6,LAMA5,TCL1A,ITGA3,GH2,RXRA,Fasl,LAMB2,LAMC1

    Protein Function

    CCNE2 has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNE2 itself. We selected most functions CCNE2 had, and list some proteins which have the same functions with CCNE2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NCKIPSD,FAM206A,SV2B,HYPK,LGALS3,PIPOX,PHOSPHO2-KLHL23,HSCB,RNF43,NTSR1
    protein kinase binding AGTR1A,RB1CC1,ACSL3,TPX2,SPAG16,PRKAB1,BCL10,GATA4,AP2A2,CCND1
    cyclin-dependent protein serine/threonine kinase regulator activity PSTPIP2,CDK4,CCNL1,CCNC,CCND1,CCNK,CKS2,CCNE1,CCNL2,CKS1B

    Interacting Protein

    CCNE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNE2.

    CDK2;CDKN1A;CDKN1B;RBL2;ORC3;E7;CDKN1C;CDK3

    CCNE2 Related Signal Pathway

    Resources

    Research Area

    Cyclins

    References

    • Du, HY; Jie, LG; et al. A Monoclonal Antibody Against a Potential Cancer Biomarker, Human Ubiquitin-Conjugating Enzyme E2. HYBRIDOMA 31:196-202(2012).
    • Nair, BC; Nair, SS; et al. Cyclin-Dependent Kinase-Mediated Phosphorylation Plays a Critical Role in the Oncogenic Functions of PELP1. CANCER RESEARCH 70:7166-7175(2010).

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