CCM2
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Official Full Name
cerebral cavernous malformation 2 -
Overview
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CCM2;cerebral cavernous malformation 2;C7orf22, chromosome 7 open reading frame 22;malcavernin;MGC4607;C7orf22;CCM2_HUMAN;Cerebral cavernous malformations 2 protein;MGC4067;MGC74868;OTTHUMP00000159554;OTTHUMP00000214270;OTTHUMP00000214271;OTTHUMP00000214273;PP10187;OSM
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rhesus macaque
- Mouse
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CCM2 involved in several pathways and played different roles in them. We selected most pathways CCM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CCM2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CCM2 itself. We selected most functions CCM2 had, and list some proteins which have the same functions with CCM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
CCM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCM2.
Resources
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References
- Tanriover, G; Sozen, B; et al. Ultrastructural analysis of vascular features in cerebral cavernous malformations. CLINICAL NEUROLOGY AND NEUROSURGERY 115:438-444(2013).
- Tanriover, G; Boylan, AJ; et al. PDCD10, the gene mutated in cerebral cavernous malformation 3, is expressed in the neurovascular unit. NEUROSURGERY 62:930-938(2008).
