CBY1
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Official Full Name
chibby homolog 1 (Drosophila) -
Overview
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CBY;arb1;PGEA1;C22orf2;PIGEA14;PIGEA-14;HS508I15A
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CBY1-1795H | Recombinant Human CBY1 protein, GST-tagged | E.coli | Human | GST | 41-126 aa | |
| CBY1-1129Z | Recombinant Zebrafish CBY1 | Mammalian Cell | Zebrafish | His |
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| CBY1-5152H | Recombinant Human CBY1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CBY1-5398C | Recombinant Chicken CBY1 | Mammalian Cell | Chicken | His |
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| CBY1-147HCL | Recombinant Human CBY1 lysate | HEK293 | Human | Non |
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| CBY1-1388H | Recombinant Human CBY1 Protein (Lys12-Glu115), His tagged | E.coli | Human | His | Lys12-Glu115 |
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| CBY1-1582H | Recombinant Human CBY1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Cby1-1978M | Recombinant Mouse Cby1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CBY1-2720H | Recombinant Human CBY1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CBY1-3781HF | Recombinant Full Length Human CBY1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 126 amino acids |
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| CBY1-4974H | Recombinant Human CBY1 protein, GST-tagged | E.coli | Human | GST | 1-126aa |
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| CBY1-596H | Recombinant Human CBY1 Protein, His-tagged | E.coli | Human | His | Lys12~Glu115 |
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| Cby1-597M | Recombinant Mouse Cby1 Protein, His-tagged | E.coli | Mouse | Non | Ile7~Lys127 |
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Involved Pathway
CBY1 involved in several pathways and played different roles in them. We selected most pathways CBY1 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Regulation of Wnt-mediated beta catenin signaling and target gene transcription,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Deactivation of the beta-catenin transactivating complex | SOX9A,TLE1,SOX4A,BCL9,TLE4,SOX6,TLE3B,SRY,SOX7,RBBP5 |
| Signal Transduction | RGS11,CNR2,LRP10,SOX13,RIT2,SHB,GPR161,RTKN,ABHD12,FMNL2 |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription | TLE4,TNIK,MYOG,SALL4,TLE2,KRT1,ZCCHC12,KCNIP4,TCF4,CDX1 |
| TCF dependent signaling in response to WNT | KLHL12,CCDC88C,SOX4B,SOX9B,LGR4,TLE3B,RSPO3,ZNRF3,WNT8-2,CDC73 |
| Signaling by Wnt | FAM123B,DACT1,C,AES,WIF1,PRICKLE1,FMNL3,TNKS,PRICKLE1B,SRY |
Protein Function
CBY1 has several biochemical functions, for example, beta-catenin binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBY1 itself. We selected most functions CBY1 had, and list some proteins which have the same functions with CBY1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SND1,KCNJ3,MBNL1,Rhox5,ZC3H14,CD2AP,EAF2,G3BP1,APOA1BP,KIAA1191 |
| identical protein binding | HNRNPC,ZNF3,C1QTNF2,DPP9,DPP4,CRYBB2,DACT3,ZNHIT6,NFKB1,C1S |
| beta-catenin binding | LZTS2A,SOX17,SMAD7,PARK2,CXADR,TBL1X,BCL9L,PTPRK,DVL3,SLC9A3R2 |
Interacting Protein
CBY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBY1.
FAM92A1;TTC23L;CFAP53;YWHAZ;CDK6;q81xy2_bacan;sbcC3;AGTPBP1;q9wmx2-pro_0000037548;YWHAE
Resources
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References
- Leo, E; Mancini, M; et al. DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of beta Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia. JOURNAL OF CELLULAR BIOCHEMISTRY 116:589-597(2015).
- Lee, YL; Sante, J; et al. Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function. MOLECULAR BIOLOGY OF THE CELL 25:2919-2933(2014).
